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Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis.
Efficacy of Biological Therapies in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis
TLDR
Biological therapies were superior to placebo in inducing remission of active CD and UC, and in preventing relapse of quiescent CD.
American College of Gastroenterology Monograph on the Management of Irritable Bowel Syndrome and Chronic Idiopathic Constipation
TLDR
The criteria developed through the Rome process, currently in its third iteration, have been those most widely employed in clinical trials and, therefore, most relevant to any review of the literature on the management of these disorders.
Prevalence of, and Risk Factors for, Chronic Idiopathic Constipation in the Community: Systematic Review and Meta-analysis
TLDR
Pooled prevalence of CIC in the community was 14%, and of similar magnitude in most geographical regions, and rates were higher in women, older individuals, and those of lower socioeconomic status.
Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis
TLDR
Antidepressants are effective in the treatment of IBS and there is less high-quality evidence for routine use of psychological therapies in IBS, but available data suggest these may be of comparable efficacy.
Antibiotic Therapy in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
TLDR
Antibiotic therapy may induce remission in active CD and UC, although the diverse number of antibiotics tested means the data are difficult to interpret.
Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome.
TLDR
In a placebo-controlled trial, the probiotic BL reduces depression but not anxiety scores and increases quality of life in patients with IBS, associated with changes in brain activation patterns that indicate that this probiotic reduces limbic reactivity.
Efficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation: Systematic Review and Meta-analysis
TLDR
Probiotics are effective treatments for IBS, although which individual species and strains are the most beneficial remains unclear, and the efficacy of all three therapies in CIC is also uncertain.
Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: systematic review and meta-analysis
TLDR
Laxatives, prucalopride, lubiprostone and linaclotide are all more effective than placebo for the treatment of CIC.
The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review
TLDR
Probiotics appear to be efficacious in IBS, but the magnitude of benefit and the most effective species and strain are uncertain.
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