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Multi-Ethnic Study of Atherosclerosis: objectives and design.
The Multi-Ethnic Study of Atherosclerosis was initiated in July 2000 to investigate the prevalence, correlates, and progression of subclinical cardiovascular disease (CVD) in a population-based sample of 6,500 men and women aged 45-84 years for identification and characterization of CVD events.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
18 new loci associated with body mass index are identified, one of which includes a copy number variant near GPRC5B, and genes in other newly associated loci may provide new insights into human body weight regulation.
Coronary calcium as a predictor of coronary events in four racial or ethnic groups.
The coronary calcium score is a strong predictor of incident coronary heart disease and provides predictive information beyond that provided by standard risk factors in four major racial and ethnic groups in the United States.
A common allele on chromosome 9 associated with coronary heart disease.
Coronary heart disease (CHD) is a major cause of death in Western countries. We used genome-wide association scanning to identify a 58-kilobase interval on chromosome 9p21 that was consistently
Carbohydrates, dietary fiber, and incident type 2 diabetes in older women.
A protective role for grains (particularly whole grains), cereal fiber, and dietary magnesium in the development of diabetes in older women is supported, after adjustment for potential nondietary confounding variables.
Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993.
Few studies have determined whether greater carotid artery intima-media thickness (IMT) in asymptomatic individuals is associated prospectively with increased risk of coronary heart disease (CHD). In
The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators.
In each of four US communities, 4,000 adults aged 45-64 years will be examined twice, three years apart, to investigate the etiology of atherosclerosis and its clinical sequelae and variation in cardiovascular risk factors, medical care, and disease by race, sex, place, and time.
Prospective study of diet and ovarian cancer.
The association of epithelial ovarian cancer with dietary factors in a prospective study of 29,083 postmenopausal women is investigated, generally in agreement with the results from previous, mostly case-control studies of diet and epithelial Ovarian cancer.
Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index
Genetic loci associated with body mass index map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor, which may provide new insights into human body weight regulation.
Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology.
The data showing no relationship of some arterial risk factors with VTE corroborate the view that the etiology of VTE differs from atherosclerotic cardiovascular disease and suggest a hypothesis that avoidance of obesity and diabetes or vigilance in prophylaxis in patients with those conditions may prevent some venous thromboses.