• Publications
  • Influence
Legionella pneumophila Induces IFNβ in Lung Epithelial Cells via IPS-1 and IRF3, Which Also Control Bacterial Replication*
Legionella pneumophila, a Gram-negative facultative intracellular bacterium, causes severe pneumonia (Legionnaires' disease). Type I interferons (IFNs) were so far associated with antiviral immunity,Expand
  • 130
  • 13
Patatin-like proteins: a new family of lipolytic enzymes present in bacteria?
Patatins are a group of plant storage glycoproteins that show lipid acyl hydrolase activity (Andrews et al., 1988). The patatin-associated lipolytic activity may be a means of defence against plantExpand
  • 108
  • 11
NAIP and Ipaf Control Legionella pneumophila Replication in Human Cells1
In mice, different alleles of the mNAIP5 (murine neuronal apoptosis inhibitory protein-5)/mBirc1e gene determine whether macrophages restrict or support intracellular replication of LegionellaExpand
  • 123
  • 7
Temporal resolution of two‐tracked NF‐κB activation by Legionella pneumophila
The intracellular pathogen Legionella pneumophila activates the transcription factor NF‐κB in macrophages and human epithelial cells, contributing to cytokine production and anti‐apoptosis. TheExpand
  • 62
  • 7
EHEC/EAEC O104:H4 strain linked with the 2011 German outbreak of haemolytic uremic syndrome enters into the viable but non-culturable state in response to various stresses and resuscitates upon
Various non-spore forming bacteria, including Escherichia coli, enter a dormant-like state, the viable but non-culturable (VBNC) state, characterized by the presence of viable cells but the inabilityExpand
  • 86
  • 7
Characterization of the Gene Encoding the Major Secreted Lysophospholipase A of Legionella pneumophila and Its Role in Detoxification of Lysophosphatidylcholine
ABSTRACT We previously showed that Legionella pneumophila secretes, via its type II secretion system, phospholipase A activities that are distinguished by their specificity for certain phospholipids.Expand
  • 95
  • 6
IFNβ responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM‐1/DAI)
Intracellular bacteria and cytosolic stimulation with DNA activate type I IFN responses independently of Toll‐like receptors, most Nod‐like receptors and RIG‐like receptors. A recent study suggestedExpand
  • 101
  • 5
Update: Multinational listeriosis outbreak due to 'Quargel', a sour milk curd cheese, caused by two different L. monocytogenes serotype 1/2a strains, 2009-2010.
We previously reported an outbreak of listeriosis in Austria and Germany due to consumption of Quargel cheese. It comprised 14 cases (including five fatalities) infected by a serotype 1/2a ListeriaExpand
  • 101
  • 5
The manifold phospholipases A of Legionella pneumophila - identification, export, regulation, and their link to bacterial virulence.
The intracellular lung pathogen Legionella pneumophila expresses secreted and cell-associated phospholipase A (PLA) and lysophospholipase A (LPLA) activities belonging to at least three enzymeExpand
  • 54
  • 4
Novel lysophospholipase A secreted by Legionella pneumophila.
We show that Legionella pneumophila possesses lysophospholipase A activity, which releases fatty acids from lysophosphatidylcholine. The NH2-terminal sequence of the enzyme contained FGDSLS,Expand
  • 59
  • 4