A. Fletcher

Publications406
h-index83
Citations33,110
Highly Influential Citations996
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Global Prevalence and Major Risk Factors of Diabetic Retinopathy
TLDR
Longer diabetes duration and poorer glycemic and blood pressure control are strongly associated with DR, and these data highlight the substantial worldwide public health burden of DR and the importance of modifiable risk factors in its occurrence.
Treatment of hypertension in patients 80 years of age or older.
TLDR
The results provide evidence that antihypertensive treatment with indapamide (sustained release), with or without perindopril, in persons 80 years of age or older is beneficial.
Global prevalence and major risk factors of diabetic retinopathy.
TLDR
The Meta-Analysis for Eye Disease (META-EYE) Study Group’s Global Prevalence and Major Risk Factors of Diabetic Retinopathy and Diabetes care, 35 (3).
Diabetes mellitus, fasting glucose, and risk of cause-specific death.
TLDR
In addition to vascular disease, diabetes is associated with substantial premature death from several cancers, infectious diseases, external causes, intentional self-harm, and degenerative disorders, independent of several major risk factors.
Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis
TLDR
Increasing age, current cigarette smoking, previous cataract surgery, and a family history of AMD showed strong and consistent associations with late AMD.
Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension
Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE).
TLDR
Age-specific prevalences of age-related maculopathy in the European Eye Study (EUREYE) are similar to other population-based studies in Western populations.
Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.
TLDR
Among elderly patients with isolated systolic hypertension, antihypertensive drug treatment starting with nitrendipine reduces the rate of cardiovascular complications and may prevent 29 strokes or 53 major cardiovascular endpoints.
Weight, shape, and mortality risk in older persons: elevated waist-hip ratio, not high body mass index, is associated with a greater risk of death.
TLDR
Current guidelines for BMI-based risk categories overestimate risks due to excess weight in persons aged >/=75 y and increased mortality risk is more clearly indicated for relative abdominal obesity as measured by high WHR.
Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies
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