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Mutations of the BRAF gene in human cancer
TLDR
BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers, with a single substitution (V599E) accounting for 80%. Expand
Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
TLDR
It is found that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis, which has important implications for the origins of genomic remodeling and temporal emergence of cancer. Expand
Kaposi sarcoma herpesvirus–induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
TLDR
It is shown by gene expression microarrays that neoplastic cells of Kaposi sarcoma are closely related to lymphatic endothelial cells (LECs) and that Kaposi Sarcoma herpesvirus (KSHV) infects both LECs and blood vascular endothelial Cells (BECs) in vitro. Expand
Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study.
TLDR
The clinical, arthroscopic and histological outcomes are comparable for both ACI-C and MACI, and while MACI is technically attractive, further long-term studies are required before the technique is widely adopted. Expand
Mammary and extramammary Paget's disease
TLDR
The concepts of primary and secondary Paget's disease are presented and the differential diagnosis is discussed with reference to immunohistochemical markers that might be of diagnostic value. Expand
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
TLDR
IDH1 and IDH2 mutations represent the first common genetic abnormalities to be identified in conventional central and periosteal cartilaginous tumours and speculate that a mosaic pattern of IDH‐mutation‐bearing cells explains the reports of diverse tumours (gliomas, AML, multiple cartILaginous neoplasms, haemangiomas) occurring in the same patient. Expand
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone
TLDR
A remarkable picture of tumor type specificity for histone H 3.3.3 driver alterations emerges, indicating that hist one H3. Expand
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
TLDR
The gene encoding the transmembrane protein tyrosine kinase ERBB2 (also known as HER2 or Neu) is sequenced from 120 primary lung tumours and 4% that have mutations within the kinase domain are identified. Expand
Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas
TLDR
It is shown that chordomas express many genes known to be involved in cartilage development, but they also uniquely express genes distinguishing them from chondroid neoplasms, and it is demonstrated that brachyury is a specific marker for the notochord andNotochord‐derived tumours. Expand
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
TLDR
This study analyzed somatic alterations in mtDNA from 1675 tumors and identified 1907 somatic substitutions, which exhibited dramatic replicative strand bias, predominantly C > T and A > G on the mitochondrial heavy strand. Expand
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