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Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
BACKGROUND Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutideExpand
The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity
Indoleamine 2, 3-dioxygenase (IDO) is the first and rate limiting catabolic enzyme in the degradation pathway of the essential amino acid tryptophan. By cleaving the aromatic indole ring ofExpand
Calcium infusion suggests a "set-point" abnormality of parathyroid gland function in familial benign hypercalcemia and more complex disturbances in primary hyperparathyroidism.
PTH clearly plays a role in maintaining the hypercalcemia of familial benign hypercalcemia (FBH or familial hypocalciuric hypocalcemia). To better define the abnormalities of parathyroid function inExpand
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Correspondence: Peggy Soule Odegard Associate Professor, School of Pharmacy, Clinical Pharmacist, Department of Medicine University of washington, 1959 NE Pacific Street, Box 357630, Seattle, wAExpand
Effects of six months of daily low-dose perchlorate exposure on thyroid function in healthy volunteers.
CONTEXT Perchlorate has been detected in U.S. drinking water supplies at levels ranging from 4 to 200 microg/liter as well as in agricultural products. Perchlorate is known to be a competitiveExpand
The Role of Dendritic Cells in Tissue-Specific Autoimmunity
In this review, we explore the role of dendritic cell subsets in the development of tissue-specific autoimmune diseases. From the increasing list of dendritic cell subclasses, it is becoming clearExpand
Improved Clinical Outcomes Using a Culturally Sensitive Diabetes Education Program in a Hispanic Population
PURPOSE The purpose of this study was to evaluate the effects of a culturally sensitive diabetes education program for Hispanics with type 2 diabetes. METHODS This study is a prospective cohortExpand
Induction of Indoleamine 2, 3-Dioxygenase in Human Dendritic Cells by a Cholera Toxin B Subunit—Proinsulin Vaccine
Dendritic cells (DC) interact with naïve T cells to regulate the delicate balance between immunity and tolerance required to maintain immunological homeostasis. In this study, immature humanExpand
Cognitive impairment and medication adherence in outpatients with heart failure.
OBJECTIVES The study objectives were (a) to describe the prevalence and severity of cognitive impairment (CI) in an outpatient veteran population with heart failure (HF), (b) to describe theExpand
Plasma intact parathyroid hormone (PTH) and PTH-related peptide in familial benign hypercalcemia: greater responsiveness to endogenous PTH than in primary hyperparathyroidism.
The cause of hypercalcemia in familial benign hypercalcemia (FBH; also called familial hypocalciuric hypercalcemia) is unclear, although it is PTH dependent. It is also uncertain how plasma PTHExpand