• Publications
  • Influence
Molecular mechanisms of dental enamel formation.
Structural analyses of recombinant amelogenin are consistent with a functional role in establishing and maintaining the spacing between enamel crystallites, and may regulate crystal habit by binding to specific faces of the mineral and inhibiting growth. Expand
The structural biology of the developing dental enamel matrix.
Current knowledge of these molecules, the probable molecular structure of the enamel matrix, and the functional role of these extracellular matrix proteins are reviewed. Expand
Characterization of Recombinant Pig Enamelysin Activity and Cleavage of Recombinant Pig and Mouse Amelogenins
It is proposed that enamelysin is the predominant proteinase that processes enamel proteins during the secretory phase of amelogenesis. Expand
Comparative Immunochemical Analyses of the Developmental Expression and Distribution of Ameloblastin and Amelogenin in Rat Incisors
Comparisons on the expression, intracellular and extracellular distribution, and dynamics of proteins representative of the two main classes of enamel matrix proteins suggest a correlation between the distribution of amelogenin and ameloblastin and that intact amelOBlastin has a transient role in promoting/stabilizing crystal elongation. Expand
Microstructures of an amelogenin gel matrix.
Observations suggest that the hydrophobic interactions among nanospheres and different orders of amelogenin assemblies are important in determining the structural integrity of the dental enamel matrix. Expand
Evidence for amelogenin "nanospheres" as functional components of secretory-stage enamel matrix.
It is postulated that the amelogenin monomers self-assemble to form nanospheres which function to space the initial crystallites, control crystal habit, inhibit intercrystalline fusions, and, through the apposition of their surfaces, create anionic channels which facilitate ion transport within the mineralizing matrix. Expand
The changing face of dental education: the impact of PBL.
The rationale for the introduction of a PBL pedagogy into dental education, the modalities of PBL being introduced, and the implications of the introduction into dental schools are discussed. Expand
Dental enamel matrix: Sequences of two amelogenin polypeptides
A striking finding was that LRAP and TRAP had identical sequences for the first 33 residues but were almost completely different for the remaining 12 amino acids. Expand
Isolation and characterization of a mouse amelogenin expressed in Escherichia coli
The purified protein was used to generate rabbit polyclonal anti-amelogenin antibodies which show specific reaction to amelogenins in both Western blot analyses of enamel extracts and in immunostaining of developing mouse molars. Expand
A Late Quaternary Paleoecological Record From Caves of Southern Jamaica, West Indies
A diverse assemblage of late Pleistocene and Holocene vertebrate remains (Table 1) have been recovered from the ~10 km Jacksons Bay cave system on the south coast of Portland Ridge, Clarendon,Expand