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Rab11‐FIP3 and FIP4 interact with Arf6 and the Exocyst to control membrane traffic in cytokinesis
It is proposed that FIP3 and FIP4 serve to couple Rab11‐positive vesicle traffic from recycling endosomes to the cleavage furrow/midbody where they are tethered prior to fusion events via interactions with Arf6 and the Exocyst.
The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.
- Gayle M Wilson, A. Fielding, R. Prekeris
- Biology, Computer ScienceMolecular biology of the cell
- 1 December 2004
It is proposed that the dynamic Rab11-FIP3 interaction controls the delivery, targeting, and fusion of recycling endosomes with furrow during late cytokinesis and abscission.
Integrin-linked kinase – essential roles in physiology and cancer biology
Accumulating evidence suggests that its oncogenic capacity derives from its regulation of several downstream targets that provide cells with signals that promote proliferation, survival and migration, supporting the concept that ILK is a relevant therapeutic target in human cancer.
Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout.
It is suggested that the novel dual GTPase-binding capacity of the arfophilins could serve as an interface of signals from Rab and Arf GTPases to regulate membrane traffic and integrate distinct signals in the late endosomal recycling compartment.
Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization
- A. Fielding, I. Dobreva, P. McDonald, L. Foster, S. Dedhar
- BiologyThe Journal of cell biology
- 25 February 2008
A critical and unexpected function for ILK is demonstrated in the organization of centrosomal protein complexes during mitotic spindle assembly and DNA segregation in RUVBL1-depleted cells.
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells
It is demonstrated that the integrin-linked kinase (ILK), a protein critically involved in actin and mitotic microtubule organization, is required for centrosome clustering and that ILK regulates this phosphorylation site in an Aurora-A-dependent manner.
Structure-Function Relationships of a Novel Bacterial Toxin, Hemolysin E
- Angela Atkins, N. R. Wyborn, Jeffrey Green
- Biology, ChemistryThe Journal of Biological Chemistry
- 29 December 2000
Gel filtration analyses suggested that immobilizing αG inhibits HlyE activity at a late stage of pore formation, whereas in solution it prevents aggregation and consequent inactivation.
Mapping the integrin-linked kinase interactome using SILAC.
Using the power of quantitative proteomics to resolve specific from nonspecific protein interactions, several novel ILK-binding proteins are identified, which sheds light on the molecular mechanisms of regulation of ILk-dependent signal transduction.
An unmet actin requirement explains the mitotic inhibition of clathrin-mediated endocytosis
It is demonstrated that CME can be “restarted” in mitotic cells despite high membrane tension, by allowing actin to engage in endocytosis.
Clathrin-mediated endocytosis is inhibited during mitosis
- A. Fielding, Anna K. Willox, E. Okeke, S. Royle
- Biology, MedicineProceedings of the National Academy of Sciences
- 9 April 2012
This study finds no support for the recent idea that endocytosis continues during mitosis, and concludes that endocytetosis is temporarily shutdown during early mitosis.