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Rab11‐FIP3 and FIP4 interact with Arf6 and the Exocyst to control membrane traffic in cytokinesis
The dual Rab11/Arf binding proteins, family of Rab11‐interacting proteins FIP3 and FIP4 function in the delivery of recycling endosomes to the cleavage furrow and are, together with Rab11, essentialExpand
The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.
An integral part of cell division is the separation of daughter cells via cytokinesis. There is now good evidence that the completion of cytokinesis requires coordinated membrane trafficking toExpand
Integrin-linked kinase – essential roles in physiology and cancer biology
Integrin-linked kinase (ILK) is a multifunctional intracellular effector of cell-matrix interactions and regulates many cellular processes, including growth, proliferation, survival, differentiation,Expand
Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout.
Arfophilin is an ADP ribosylation factor (Arf) binding protein of unknown function. It is identical to the Rab11 binding protein eferin/Rab11-FIP3, and we show it binds both Arf5 and Rab11. WeExpand
Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization
Integrin-linked kinase (ILK) is a serine-threonine kinase and scaffold protein with well defined roles in focal adhesions in integrin-mediated cell adhesion, spreading, migration, and signaling.Expand
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells
Many cancer cells contain more than two centrosomes, which imposes a potential for multipolar mitoses, leading to cell death. To circumvent this, cancer cells develop mechanisms to clusterExpand
Structure-Function Relationships of a Novel Bacterial Toxin, Hemolysin E
The novel pore-forming toxin hemolysin E (HlyE, ClyA, or SheA) consists of a long four-helix bundle with a subdomain (β tongue) that interacts with target membranes at one pole and an additionalExpand
Mapping the integrin-linked kinase interactome using SILAC.
Protein-protein interactions play an essential role in the regulation of vital biological functions. Through a network of interactions, integrin-linked kinase (ILK) functions downstream of integrinExpand
An unmet actin requirement explains the mitotic inhibition of clathrin-mediated endocytosis
Clathrin-mediated endocytosis (CME) is the major internalisation route for many different receptor types in mammalian cells. CME is shut down during early mitosis, but the mechanism of thisExpand
Clathrin-mediated endocytosis is inhibited during mitosis
A long-standing paradigm in cell biology is the shutdown of endocytosis during mitosis. There is consensus that transferrin uptake is inhibited after entry into prophase and that it resumes inExpand