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Noninvasive Diagnosis of Hypolactasia With 4-Galactosylxylose (Gaxilose): A Multicentre, Open-Label, Phase IIB-III Nonrandomized Trial
- J. J. Aragón, Carmen Hermida, Pilar Martínez
- MedicineJournal of clinical gastroenterology
- 1 January 2014
The diagnostic performance of the gaxilose tests is excellent and can substantially improve the diagnosis of hypolactasia.
Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System
- M. Nieto‐Sampedro, B. Valle-Argos, D. Gomez-Nicola, A. Fernández-Mayoralas, M. Nieto-Díaz
- BiologyClinical Medicine Insights. Oncology
- 1 January 2011
The ability of gliomas to evade and suppress the host immune system, exhibited at the levels of antigen recognition and immune activation, limiting the effective signaling between glioma and host immune cells is examined.
Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs.
- G. Abraham, A. Gallardo, J. San Román, A. Fernández-Mayoralas, M. Zurita, J. Vaquero
- Materials Science, BiologyJournal of biomedical materials research. Part A
- 15 March 2003
The in vitro aqueous behavior of four drug-loaded and unloaded graft copolymers of different MMA: DMAm and PCL ratios has been analyzed performing swelling, degradation, and drug release experiments and an intimate dependence of the aqueously behavior with the composition has been found.
Phase I and Phase IB Clinical Trials for the Noninvasive Evaluation of Intestinal Lactase With 4-Galactosylxylose (Gaxilose)
The methodology described provides a simple, safe test for the evaluation of lactase activity in vivo and further evaluation of the test as a noninvasive diagnosis of hypolactasia is ongoing in patients with lactose intolerance.
Synthesis and biological studies of glycosyl dopamine derivatives as potential antiparkinsonian agents.
Synthesis of glycosyl derivatives as dopamine prodrugs: interaction with glucose carrier GLUT-1.
- C. Fernández, O. Nieto, J. A. Fontenla, E. Rivas, M. L. de Ceballos, A. Fernández-Mayoralas
- Chemistry, BiologyOrganic & biomolecular chemistry
- 27 February 2003
Glucosyl dopamine (DA) derivatives may represent a new class of DA prodrugs that would interact with glucose transporter GLUT-1, present in the blood-brain barrier, and generate DA in the brain.…
Conformational Behavior of Aza-C-Glycosides: Experimental Demonstration of the Relative Role of the exo-anomeric Effect and 1,3-Type Interactions in Controlling the Conformation of Regular Glycosides
The conformational behavior of different aza-C-glycosides synthesized as glycosidase inhibitors has been studied using a combination of NMR spectroscopy (J and NOE data) and time-averaged restrained…
Use of cyclic sulfamidates derived from D-allosamine in nucleophilic displacements: Scope and limitations
Purification and Structure of Neurostatin, an Inhibitor of Astrocyte Division of Mammalian Brain
- J. Abad-Rodríguez, M. Bernabé, L. Romero-Ramírez, M. Vallejo-Cremades, A. Fernández-Mayoralas, M. Nieto‐Sampedro
- Biology, ChemistryJournal of neurochemistry
- 1 June 2000
Mono‐ and bidimensional NMR spectra, together with biochemical studies, suggest that neurostatin may be the 9‐O‐monoacetyl ester of GD1b, which is cytostatic for astroblasts, C6 glioma cells, and various human astrocytomas grades III and IV.
Nucleophilic displacements on a cyclic sulfamidate derived from allosamine: application to the synthesis of thiooligosaccharides
The cyclic sulfamidate of the allosamine derivative 11 is efficiently prepared by reaction with 1,1′-sulfuryl diimidazole and furnishes 3-thioglucosamine derivatives, useful intermediates in synthesis of thiooligosaccharides.