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Expansion of NK Cells and Reduction of NKG2D Expression in Chronic Lymphocytic Leukemia. Correlation with Progressive Disease
TLDR
The expansion of NK cells and the reversibility of NK cell defects provide new opportunities for the immunotherapeutic intervention in CLL. Expand
Prognostic significance of CD8 and CD4 T cells in chronic lymphocytic leukemia
The prognostic value of the number of T cells and NK cells at diagnosis in CLL was analyzed in a cohort of 256 patients with CLL diagnosed between 1997 and 2007. Patients with leukemia showedExpand
Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells
TLDR
It is demonstrated that dentate gyrus granule cells are not required for memory retrieval, but instead have an unexpected role in memory maintenance and open a new avenue for the targeted erasure of episodic and contextual memories. Expand
Patients with psoriatic arthritis may show differences in their clinical and genetic profiles depending on their age at psoriasis onset.
TLDR
Clinical and genetic features of PsA may differ depending on the age at psoriasis onset, and this type of stratification should be considered in future genetic and epidemiological studies of psA. Expand
Expression of ERp5 and GRP78 on the membrane of chronic lymphocytic leukemia cells: association with soluble MICA shedding
TLDR
A molecular mechanism which regulates MICA protein shedding and immune evasion in CLL is uncovered, which is associated with the down-modulation of NKG2D surface expression on CD8 T cells. Expand
The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.
TLDR
Evidence is presented that the binding of DIG-MSK to DNA shares the general features of other mithramycins such as the preference for C/G-rich tracts, but there are some differences in the strength of binding and the DNA sequence preferentially recognized by DIG -MSK. Expand
Lenalidomide Induces Immunomodulation in Chronic Lymphocytic Leukemia and Enhances Antitumor Immune Responses Mediated by NK and CD4 T Cells
TLDR
Observations provide a support for combining lenalidomide with rituximab as a treatment in CLL and show that lenalidumide treatment does not have an effect on the proliferation of leukemia cells, but it increases the proliferationof B cells from healthy donors. Expand
A Differential and Timed Contribution of Identified Hippocampal Synapses to Associative Learning in Mice.
TLDR
Results confirm that the acquisition of a classical eyeblink conditioning is a multisynaptic process in which the contribution of each synaptic contact is different in strength, and takes place at different moments across learning. Expand
Pleiotropic Anti-Angiogenic and Anti-Oncogenic Activities of the Novel Mithralog Demycarosyl-3D-ß-D-Digitoxosyl-Mithramycin SK (EC-8042)
TLDR
It is shown that DIG-MSK displays a potent anti-tumor activity against different types of cancer cell lines, ovarian tumor cells being particularly sensitive to this drug. Expand
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