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A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays
A suite of computational tools that incorporate state-of-the-art statistical techniques for the analysis of DNAm data are described that include methods for preprocessing, quality assessment and detection of differentially methylated regions from the kilobase to the megabase scale.
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
Methylation changes in cancer are at sites that vary normally in tissue differentiation, consistent with the epigenetic progenitor model of cancer, which proposes that epigenetic alterations affecting tissue-specific differentiation are the predominant mechanism by which epigenetic changes cause cancer.
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
It is demonstrated that two enzymes cooperatively maintain DNA methylation and gene silencing in human cancer cells, and compelling evidence that such methylation is essential for optimal neoplastic proliferation is provided.
The epigenetic progenitor origin of human cancer
This work suggests that non-neoplastic but epigenetically disrupted stem/progenitor cells might be a crucial target for cancer risk assessment and chemoprevention.
The history of cancer epigenetics
This timeline traces the field from its conception to the present day and addresses the genetic basis of epigenetic changes — an emerging area that promises to unite cancer genetics and epigenetics, and might serve as a model for understanding the epigenetic basis of human disease more generally.
Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19.
The first evidence, to the knowledge, is reported that ART is associated with a human overgrowth syndrome-namely, Beckwith-Wiedemann syndrome (BWS), similar to the large offspring syndrome reported in ruminants.
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in Rheumatoid Arthritis
DNA methylation is a potential mediator of genetic risk for rheumatoid arthritis and is corrected for cellular heterogeneity by estimating and adjusting for cell-type proportions in blood-derived DNA samples and used mediation analysis to filter out associations likely to be a consequence of disease.
Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies.
A data analysis pipeline is presented that effectively models measurement error, removes batch effects, detects regions of interest and attaches statistical uncertainty to identified regions, and shows that addressing unexplained heterogeneity like batch effects reduces the number of false-positive regions.
BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting…
- D. Loukinov, E. Pugacheva, Victor V Lobanenkov
- BiologyProceedings of the National Academy of Sciences…
- 14 May 2002
It is shown here that erasure of methylation marks during male germ-line development is associated with dramatic up- regulation of BORIS and down-regulation of CTCF expression, and BORis is a candidate protein for the elusive epigenetic reprogramming factor acting in the male germ line.