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On the function of BMP‐4 in patterning the marginal zone of the Xenopus embryo.
TLDR
It is argued that BMP‐4 may act in vivo as a ventral signal for the proper patterning of the marginal zone, actively interacting with dorsal genes such as gsc and Xnot‐2. Expand
The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4
TLDR
It is reported that follistatin antagonizes the activities of BMP-4 in frog embryos and mouse teratocarcinoma cells, and it is shown that the follistatins and B MP-4 proteins can interact directly in vitro. Expand
Scaling of the BMP activation gradient in Xenopus embryos
TLDR
Evidence is presented that in Xenopus, the BMP activity gradient is defined by a ‘shuttling-based’ mechanism, whereby the B MPs ligands are translocated ventrally through their association with the B MP inhibitor Chordin, which accounts naturally for the scaling of embryo pattern with its size. Expand
Isolation and characterization of target sequences of the chicken CdxA homeobox gene.
TLDR
The DNA sequence specificity of the CDXA protein is determined and it is shown that this protein can further activate transcription in cells in culture and is capable of enhancing the transcriptional activity of reporter plasmids when introduced intoCDXA expressing cells. Expand
The role of gsc and BMP‐4 in dorsal‐ventral patterning of the marginal zone in Xenopus: a loss‐of‐function study using antisense RNA.
TLDR
Both gain‐ and loss‐of‐function results for gsc and BMP‐4 support the view that these two genes are necessary components of the dorsal and ventral patterning pathways in Xenopus embryos. Expand
Patterning of the embryo along the anterior-posterior axis: the role of the caudal genes.
TLDR
The results show that the caudal genes are part of a posterior determining network which during early gastrulation functions in the subdivision of the embryo into anterior head and trunk domains and later in Gastrulation and neurulation these genes play a role in the patterning of the trunk region. Expand
Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels.
TLDR
The model suggests that FASD is induced in part by an ethanol-dependent reduction in retinoic acid levels that are necessary for the normal function of Spemann's organizer. Expand
Oct‐3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β‐catenin signalling
TLDR
Genetic and biochemical studies are presented that suggest an unexpected novel strategy for Oct‐3/4‐dependent regulation of embryogenesis and cell lineage determination that specifically interacts with nuclear β‐catenin and facilitates its proteasomal degradation, resulting in the maintenance of an undifferentiated, early embryonic phenotype. Expand
Expression of the novel murine homeobox gene Sax-1 in the developing nervous system
TLDR
Sax-1 was found to be transiently expressed in the developing posterior CNS, first seen in the ectoderm lateral to the primitive streak, the signal later encompassed the neural plate and was delimited by the Pax-6 signal in the neural tube. Expand
Patterning of the mesoderm involves several threshold responses to BMP-4 and Xwnt-8
TLDR
The data support the view that Xwnt-8 is involved in the specification of lateral (somitogenic) mesoderm and BMP-4 in the Specification of ventral mesodeter, and the spatial distribution and the level of B MP-4 activity in the lateral and ventral marginal zone is reflected in the dynamic expression pattern. Expand
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