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1 Hemoglobin Structure and Function
This chapter describes the hemoglobin (Hb) structure and function in fishes. Hb of most vertebrates is a tetrameric globular protein consisting of two α and two β polypeptide chains, each having anExpand
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Nitrate and nitrite in biology, nutrition and therapeutics.
Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as anExpand
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Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities.
The reduction of circulating nitrite to nitric oxide (NO) has emerged as an important physiological reaction aimed to increase vasodilation during tissue hypoxia. Although hemoglobin, xanthineExpand
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Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation.
In catalyzing the reversible hydration of CO2 to bicarbonate and protons, the ubiquitous enzyme carbonic anhydrase (CA) plays a crucial role in CO2 transport, in acid-base balance, and in linkingExpand
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The haemoglobin system of the mudfish, Labeo capensis: adaptations to temperature and hypoxia
Abstract The effect of temperature and hypoxic acclimation on the haemoglobin system and intraerythrocytic organic phosphate concentrations in the South African mudfish, Labeo capensis , have beenExpand
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The case of the missing NO– hemoglobin: Spectral changes suggestive of heme redox reactions reflect changes in NO– heme geometry
When low levels of gaseous nitric oxide (NO) are equilibrated with deoxygenated Hb, all NO added can be accounted for in terms of hexacoordinate and pentacoordinate forms of NO–Hb, despite recentExpand
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Critical redox and allosteric aspects of nitric oxide interactions with hemoglobin.
Nitric oxide (NO) is an important signaling molecule. Relatively long-lived NO adducts at the heme and SH groups of hemoglobin (Hb) could enable NO to carry out long-range signaling functions. InExpand
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Hemoglobins from Plasmodium-infected rat erythrocytes: functional and molecular characteristics.
Aiming to evaluate the mechanisms responsible for altered O2-transporting properties in blood of Plasmodium-infected animals, stripped (cofactor-free) hemoglobin (Hb) solutions were prepared fromExpand
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The role of blood nitrite in the control of hypoxic vasodilation
Abstract In the past few years circulating nitrite has been increasingly regarded not only as an inert end-product of endogenous nitric oxide (NO), but also as an important physiological compoundExpand
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Enhancing effects of acetazolamide on neuronal activity correlate with enhanced visual processing ability in humans
Acetazolamide is a potent inhibitor of the reversible hydration of CO(2) catalyzed by the enzyme carbonic anhydrase and is commonly used to increase cerebral blood flow e.g. in order to estimateExpand
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