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The role of excitatory amino acids and NMDA receptors in traumatic brain injury.
TLDR
Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular glutamate and aspartate adjacent to the trauma site, which contributes to delayed tissue damage after brain trauma.
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Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury
TLDR
Results implicate caspase-3-like proteases in neuronal apoptosis induced by TBI and suggest that the blockade of such caspases can reduce post-traumatic apoptosis and associated neurological dysfunction.
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Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies.
  • D. Loane, A. Faden
  • Biology, Psychology
    Trends in pharmacological sciences
  • 1 December 2010
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Sustained sensory/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouse.
TLDR
These findings demonstrate sustained and reproducible deficits in sensory/motor function and spatial learning in the CCI-injured mouse correlating with injury severity, as well as strategies for evaluating novel pharmacological treatment strategies.
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Endogenous Repair after Spinal Cord Contusion Injuries in the Rat
TLDR
Observations suggest that the endogenous reparative response to spinal contusion injury is substantial, and the regulation and restrictions on the repair processes might lead to better ways in which to encourage spontaneous recovery after CNS injury.
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Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation.
TLDR
Persistent microglial activation was observed in the injured cortex through 1 year after injury and was associated with progressive lesion expansion, hippocampal neurodegeneration, and loss of myelin.
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MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study.
TLDR
Results indicate that inexperienced observers can learn quickly to assign consistent BBB scores that approach those given by experienced teams, that the scores are most consistent between 4 and 16, and that experience improves consistency of team scores.
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Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states
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Differential Expression of Apoptotic Protease-Activating Factor-1 and Caspase-3 Genes and Susceptibility to Apoptosis during Brain Development and after Traumatic Brain Injury
TLDR
It is demonstrated that, during brain maturation, the potential of the intrinsic apoptotic pathway is progressively reduced and that such repression is associated with downregulation of apoptotic protease-activating factor-1 (Apaf-1) and caspase-3 gene expression.
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Cell death mechanisms and modulation in traumatic brain injury
View on Springer
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