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Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum.
  • A. Fabiato
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 May 1992
The hypothesis of a Ca2+-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) is supported by experiments done in skinned cardiac cells (sarcolemma removed by microdissection). AccordingExpand
  • 894
  • 74
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Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands.
  • A. Fabiato
  • Chemistry, Medicine
  • Methods in enzymology
  • 1988
Publisher Summary This chapter focuses on the computer programs for calculating total from specified free, or free from specified total ionic concentrations in aqueous solutions containing multipleExpand
  • 997
  • 71
Time and calcium dependence of activation and inactivation of calcium- induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell
  • A. Fabiato
  • Chemistry, Medicine
  • The Journal of general physiology
  • 1 February 1985
Microprocessor-controlled changes of [free Ca2+] at the outer surface of the sarcoplasmic reticulum (SR) wrapped around individual myofibrils of a skinned canine cardiac Purkinje cell and aequorinExpand
  • 882
  • 49
  • PDF
Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles.
1. The effects of decreasing pH from 7.40 to 6.20 on the tension developed by direct activation of the myofilaments and by Ca2+ release from the sarcoplasmic reticulum were studied comparatively inExpand
  • 1,111
  • 34
Calcium release from the sarcoplasmic reticulum.
Calcium that induces contraction by interacting with the contractile proteins of muscle cells may be derived from different sources: extracellular space including the basement membrane, sarcoplasmicExpand
  • 701
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Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell
  • A. Fabiato
  • Chemistry, Medicine
  • The Journal of general physiology
  • 1 February 1985
Skinned canine cardiac Purkinje cells were stimulated by regularly repeated microinjection-aspiration sequences that were programmed to simulate the fast initial component of the transsarcolemmalExpand
  • 446
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Contractions induced by a calcium‐triggered release of calcium from the sarcoplasmic reticulum of single skinned cardiac cells.
1. Fragments of single cardiac cells were obtained by homogenization of ventricular tissue from adult rats. Remaining pieces of sacrolemma were removed by micro‐dissection. Tension was recorded fromExpand
  • 670
  • 17
Myoplasmic free calcium concentration reached during the twitch of an intact isolated cardiac cell and during calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned cardiac
  • A. Fabiato
  • Medicine, Chemistry
  • The Journal of general physiology
  • 1 November 1981
Intact cardiac cells from the adult rat or rabbit ventricle were isolated by enzymatic digestion with a progressive increase of the [free Ca2+] in the solution. These cells were electricallyExpand
  • 521
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CALCIUM‐INDUCED RELEASE OF CALCIUM FROM THE SARCOPLASMIC RETICULUM OF SKINNED CELLS FROM ADULT HUMAN, DOG, CAT, RABBIT, RAT, AND FROG HEARTS AND FROM FETAL AND NEW‐BORN RAT VENTRICLES *
The small transsarcolemmal influx of Ca2+ during the action potential is by itself insufficient t o activate the myofilaments of mammalian cardiac muscle.’ It has been suggested that this smallExpand
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