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Two families of GTPases dominate the complex cellular response to IFN-gamma.
IFN-gamma induces a number of cellular programs functional in innate and adaptive resistance to infectious pathogens. It has recently become clear that the complete cellular response to IFN-gamma isExpand
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PUMA‐G, an IFN‐γ‐inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily
IFN‐γ is a key immunoregulatory cytokine that plays a predominant role in innate immunity. By employing PCR‐Select to search for genes differentially expressed in IFN‐γ/TNF‐α stimulated macrophages,Expand
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Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle
Most carcinomas present some form of chromosome instability in combination with spindle defects. Numerical instability is likely caused by spindle aberrations, but the origin of breaks andExpand
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Signal Via Lymphotoxin-βR on Bone Marrow Stromal Cells Is Required for an Early Checkpoint of NK Cell Development1
NK cells play an important role in the immune system but the cellular and molecular requirements for their early development are poorly understood. Lymphotoxin-α (LTα)−/− and LTβR−/− mice show aExpand
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Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosis
Synapsis of homologous chromosomes is a key meiotic event, mediated by a large proteinaceous structure termed the synaptonemal complex. Here, we describe a role in meiosis for the murineExpand
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Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development
The death inducer obliterator (Dido) locus encodes three protein isoforms, of which Dido3 is the largest and most broadly expressed. Dido3 is a nuclear protein that forms part of the spindle assemblyExpand
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Dido3 PHD modulates cell differentiation and division.
Death Inducer Obliterator 3 (Dido3) is implicated in the maintenance of stem cell genomic stability and tumorigenesis. Here, we show that Dido3 regulates the expression of stemness genes in embryonicExpand
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Death inducer obliterator protein 1 in the context of DNA regulation
Death inducer obliterator protein 1 [DIDO1; also termed DIO‐1 and death‐associated transcription factor 1 (DATF‐1)] is encoded by a gene thus far described only in higher vertebrates. Current geneExpand
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Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms.
The myelodysplastic/myeloproliferative diseases (MDS/MPDs) are a heterogeneous group of myeloid neoplasms that share characteristics with chronic myeloproliferative diseases and myelodysplasticExpand
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Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability
Numerical and/or structural centrosome abnormalities have been correlated with most solid tumors and hematological malignancies. Tumorigenesis also is linked to defects in the mitotic or spindleExpand
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