• Publications
  • Influence
Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change.
The prevalence of adaptive evolution relative to genetic drift is a central problem in molecular evolution. Methods to estimate the fraction of adaptive nucleotide substitutions (alpha) have beenExpand
  • 378
  • 62
  • PDF
Adaptive protein evolution in Drosophila
For over 30 years a central question in molecular evolution has been whether natural selection plays a substantial role in evolution at the DNA sequence level. Evidence has accumulated over the lastExpand
  • 618
  • 61
  • PDF
The distribution of fitness effects of new mutations
The distribution of fitness effects (DFE) of new mutations is a fundamental entity in genetics that has implications ranging from the genetic basis of complex disease to the stability of theExpand
  • 1,046
  • 52
  • PDF
Joint Inference of the Distribution of Fitness Effects of Deleterious Mutations and Population Demography Based on Nucleotide Polymorphism Frequencies
The distribution of fitness effects of new mutations (DFE) is important for addressing several questions in genetics, including the nature of quantitative variation and the evolutionary fate of smallExpand
  • 311
  • 42
  • PDF
The Distribution of Fitness Effects of New Deleterious Amino Acid Mutations in Humans
The distribution of fitness effects of new mutations is a fundamental parameter in genetics. Here we present a new method by which the distribution can be estimated. The method is fairly robust toExpand
  • 317
  • 36
  • PDF
Changing effective population size and the McDonald-Kreitman test.
Artifactual evidence of adaptive amino acid substitution can be generated within a McDonald-Kreitman test if some amino acid mutations are slightly deleterious and there has been an increase inExpand
  • 223
  • 32
  • PDF
The genomic rate of adaptive evolution.
  • A. Eyre-Walker
  • Biology, Medicine
  • Trends in ecology & evolution
  • 1 October 2006
The role of positive darwinian selection in evolution at the molecular level has been keenly debated for many years, with little resolution. However, a recent increase in DNA sequence data and theExpand
  • 282
  • 28
  • PDF
Genome wide analyses reveal little evidence for adaptive evolution in many plant species.
The relative contribution of advantageous and neutral mutations to the evolutionary process is a central problem in evolutionary biology. Current estimates suggest that whereas Drosophila, mice, andExpand
  • 230
  • 28
  • PDF
The genomic rate of adaptive amino acid substitution in Drosophila.
The proportion of amino acid substitutions driven by adaptive evolution can potentially be estimated from polymorphism and divergence data by an extension of the McDonald-Kreitman test. We haveExpand
  • 218
  • 27
  • PDF
Variation in the mutation rate across mammalian genomes
It has been known for many years that the mutation rate varies across the genome. However, only with the advent of large genomic data sets is the full extent of this variation becoming apparent. TheExpand
  • 344
  • 23
  • PDF