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- Publications
- Influence
Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change.
- A. Eyre-Walker, P. Keightley
- Biology, Medicine
- Molecular biology and evolution
- 1 September 2009
The prevalence of adaptive evolution relative to genetic drift is a central problem in molecular evolution. Methods to estimate the fraction of adaptive nucleotide substitutions (alpha) have been… Expand
Adaptive protein evolution in Drosophila
- N. G. Smith, A. Eyre-Walker
- Biology, Medicine
- Nature
- 28 February 2002
For over 30 years a central question in molecular evolution has been whether natural selection plays a substantial role in evolution at the DNA sequence level. Evidence has accumulated over the last… Expand
The distribution of fitness effects of new mutations
- A. Eyre-Walker, P. Keightley
- Biology, Medicine
- Nature Reviews Genetics
- 1 August 2007
The distribution of fitness effects (DFE) of new mutations is a fundamental entity in genetics that has implications ranging from the genetic basis of complex disease to the stability of the… Expand
Joint Inference of the Distribution of Fitness Effects of Deleterious Mutations and Population Demography Based on Nucleotide Polymorphism Frequencies
- P. Keightley, A. Eyre-Walker
- Biology, Medicine
- Genetics
- 1 December 2007
The distribution of fitness effects of new mutations (DFE) is important for addressing several questions in genetics, including the nature of quantitative variation and the evolutionary fate of small… Expand
The Distribution of Fitness Effects of New Deleterious Amino Acid Mutations in Humans
- A. Eyre-Walker, M. Woolfit, Ted Phelps
- Biology, Medicine
- Genetics
- 1 June 2006
The distribution of fitness effects of new mutations is a fundamental parameter in genetics. Here we present a new method by which the distribution can be estimated. The method is fairly robust to… Expand
Changing effective population size and the McDonald-Kreitman test.
- A. Eyre-Walker
- Biology, Medicine
- Genetics
- 1 December 2002
Artifactual evidence of adaptive amino acid substitution can be generated within a McDonald-Kreitman test if some amino acid mutations are slightly deleterious and there has been an increase in… Expand
The genomic rate of adaptive evolution.
- A. Eyre-Walker
- Biology, Medicine
- Trends in ecology & evolution
- 1 October 2006
The role of positive darwinian selection in evolution at the molecular level has been keenly debated for many years, with little resolution. However, a recent increase in DNA sequence data and the… Expand
Genome wide analyses reveal little evidence for adaptive evolution in many plant species.
- Toni I Gossmann, B. Song, +5 authors A. Eyre-Walker
- Medicine, Biology
- Molecular biology and evolution
- 1 August 2010
The relative contribution of advantageous and neutral mutations to the evolutionary process is a central problem in evolutionary biology. Current estimates suggest that whereas Drosophila, mice, and… Expand
The genomic rate of adaptive amino acid substitution in Drosophila.
- N. Bierne, A. Eyre-Walker
- Biology, Medicine
- Molecular biology and evolution
- 1 July 2004
The proportion of amino acid substitutions driven by adaptive evolution can potentially be estimated from polymorphism and divergence data by an extension of the McDonald-Kreitman test. We have… Expand
Variation in the mutation rate across mammalian genomes
- Alan Hodgkinson, A. Eyre-Walker
- Biology, Medicine
- Nature Reviews Genetics
- 1 November 2011
It has been known for many years that the mutation rate varies across the genome. However, only with the advent of large genomic data sets is the full extent of this variation becoming apparent. The… Expand