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Punding in Parkinson's disease: Its relation to the dopamine dysregulation syndrome
Punding is a term that was coined originally to describe complex prolonged, purposeless, and stereotyped behaviour in chronic amphetamine users. A structured interview of 50 patients with higherExpand
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Compulsive drug use linked to sensitized ventral striatal dopamine transmission
A small group of Parkinson's disease (PD) patients compulsively use dopaminergic drugs despite causing harmful social, psychological, and physical effects and fulfil core Diagnostic and StatisticalExpand
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Dopamine dysregulation syndrome, impulse control disorders and punding after deep brain stimulation surgery for Parkinson’s disease
Data regarding the effect of deep brain stimulation (DBS) surgery on the dopamine dysregulation syndrome (DDS), impulse control disorders (ICDs) and punding in Parkinson's disease (PD) are limited.Expand
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Clinical spectrum of impulse control disorders in Parkinson's disease
Impulse control disorders (ICDs), including compulsive gambling, buying, sexual behavior, and eating, are a serious and increasingly recognized psychiatric complication in Parkinson's disease (PD).Expand
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Pathological gambling in Parkinson's disease: Risk factors and differences from dopamine dysregulation. An analysis of published case series
Pathological gambling (PG) has been reported as a complication of the treatment of Parkinson's disease (PD). We examined all published cases of PG for prevalence and risk factors of thisExpand
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Factors influencing susceptibility to compulsive dopaminergic drug use in Parkinson disease
Background: In the course of treatment, a small group of patients with Parkinson disease (PD) develop a harmful pattern of compulsive dopaminergic drug use, called the dopamine dysregulation syndromeExpand
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Clinical correlates of levodopa-induced dopamine release in Parkinson disease
Objective: To evaluate the relationship between clinical improvement and in vivo synaptic dopamine (DA) release after a single oral dose of levodopa (LD) in patients with advanced Parkinson diseaseExpand
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Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours.
Impulsive-compulsive behaviours are a significant source of morbidity for patients with Parkinson's disease receiving dopaminergic therapy. The development of these behaviours may reflectExpand
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Impulsive and compulsive behaviors in Parkinson's disease
Antiparkinson therapy can be the primary cause of a range of nonmotor symptoms that include a set of complex disinhibitory psychomotor pathologies and are linked by their repetitive, reward orExpand
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Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry?
Dopamine replacement therapy (DRT) is the most effective treatment for Parkinson's disease (PD); it provides substantial benefit for most patients, extends independence, and increases survival. A fewExpand
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