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Recovery of Postischemic Brain Metabolism and Function Following Treatment with a Free Radical Scavenger and Platelet‐Activating Factor Antagonists
- D. D. Gilboe, D. Kintner, +4 authors N. G. Bazan
- Chemistry, Medicine
- Journal of neurochemistry
- 1 January 1991
Abstract: We have studied the metabolic and functional effects of two new platelet‐activating factor (PAF) antagonists (BN 50726 and BN 50739) and their diluent (dimethyl sulfoxide; DMSO) during… Expand
Stimulation of K+ fluxes by diuretic drugs in human red cells.
Two different families of diuretic drugs--(i) (aryloxy)acetic acid diuretics (ethacrynic acid, tienilic acid and (--)-indacrinone) and (ii) furopyridines [(+/-)-BN 50157 and… Expand
Evidence that mammalian lignans show endogenous digitalis-like activities.
- M. Fagoo, P. Braquet, J. P. Robin, A. Esanu, T. Godfraind
- Biology, Medicine
- Biochemical and biophysical research…
- 13 February 1986
Enterolactone, a lignan that has been identified in biological samples from man and several mammals, shares with ascorbic acid and cardiac glycosides a gamma-butyrolactone. It displaces 3H-ouabain… Expand
Endogenous lignans--a potential endogenous digitalis.
- P. Braquet, N. Senn, J. P. Robin, A. Esanu, R. Garay
- Journal of hypertension. Supplement : official…
- 1 December 1986
Lignans are natural products formed by oxidative dimerization of monomeric phenols. A few were recently discovered in human and animal urine, semen and blood plasma but their role has never been… Expand
Inhibition of the erythrocyte Na+, K+-pump by mammalian lignans.
- P. Braquet, N. Senn, J. P. Robin, A. Esanu, T. Godfraind, R. Garay
- Chemistry, Medicine
- Pharmacological research communications
- 1 March 1986
Several mammalian lignans, particularly enterolactone, 3-oxy-methyl enterolactone and prestegane B are able to inhibit Na+, K+-pump activity in human red cells with IC50 of about 1 mM. The inhibition… Expand
Recent progress in ginkgolide research
Gaps and perspectives of new fluoroquinolones.
The gaps in the present piperazinyl-substituted fluoroquinolones include: (a) gaps in their antibacterial spectrum, varying from one fluoroquinolone to another for… Expand
Cicletanine Improves Myocardial Function Deteriorated by Ischemia/Reperfusion in Isolated Working Rat Hearts
- P. Ferdinandy, M. Koltai, +4 authors P. Braquet
- Journal of cardiovascular pharmacology
- 1 February 1992
Summary The effect of cicletanine, a novel furopyridine antihypertensive drug was compared with that of nitren-dipine, a dihydropyridine slow calcium channel blocker, on cardiac function and… Expand
Effect of BN 50739, a new platelet activating factor antagonist, on ischaemia induced ventricular arrhythmias in isolated working rat hearts.
STUDY OBJECTIVE The aim was to investigate the role of platelet activating factor (PAF) in myocardial ischaemia by using BN 50739, a new specific PAF receptor antagonist with a hetrazepine framework.… Expand
Cicletanine attenuates overdrive pacing‐induced global myocardial ischemia in rabbits: possible role of cardiac cyclic nucleotides
BackgroundThis study examined whether cicletanine, an antihypertensive drug with cGMP phosphodiesterase inhibitory effect, could alleviate ventricular overdrive pacing-induced myocardial ischemia in… Expand