oskar organizes the germ plasm and directs localization of the posterior determinant nanos
- A. Ephrussi, L. K. Dickinson, R. Lehmann
- 12 July 1991
Induction of germ cell formation by oskar
- A. Ephrussi, R. Lehmann
- 30 July 1992
The oskar gene directs germ plasm assembly and controls the number of germ cell precursors formed at the posterior pole of the Drosophila embryo. Mislocalization of oskar RNA to the anterior pole…
mRNA Localization: Gene Expression in the Spatial Dimension
- K. Martin, A. Ephrussi
- 20 February 2009
Tribbles Coordinates Mitosis and Morphogenesis in Drosophila by Regulating String/CDC25 Proteolysis
- J. Mata, Silvia Curado, A. Ephrussi, P. Rørth
- 26 May 2000
Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning.
- G. Jiménez, A. Guichet, A. Ephrussi, J. Casanova
- BiologyGenes & Development
- 15 January 2000
Evidence that Tor signaling regulates terminal patterning by inactivating Cic at the embryo poles is presented, suggesting that Cic-like proteins may act as repressors regulated by RTK signaling in other organisms.
Translational control of oskar generates short OSK, the isoform that induces pole plasma assembly.
- F. Markussen, A. Michon, W. Breitwieser, A. Ephrussi
- 1 November 1995
The targeting of oskar activity to the posterior pole involves two steps of spatial restriction, cytoskeleton-dependent localization of the mRNA and localization-dependent translation, and it is demonstrated that two isoforms of Oskar protein are produced by alternative start codon usage.
Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport
- O. Hachet, A. Ephrussi
- BiologyCurrent Biology
- 30 October 2001
B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo.
- A. Ephrussi, G. Church, S. Tonegawa, W. Gilbert
- Biology, ChemistryScience
- 11 January 1985
There are changes in the reactivity of guanine residues to dimethyl sulfate within the enhancer sequence in myeloma, B, and early B cells, whereas virtually no alterations appear in cells of non-B lineage.
Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization
- O. Hachet, A. Ephrussi
- 29 April 2004
It is shown that splicing at the first exon–exon junction of oskar RNA is essential for oskarsar mRNA localization at the posterior pole and that the localization of unrelated transcripts bearing the oSkar 3′UTR is mediated by endogenous oskara mRNA, revealing an important new function for splicing.