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Carbapenems: Past, Present, and Future
- K. Papp-Wallace, A. Endimiani, M. Taracila, R. Bonomo
- BiologyAntimicrobial Agents and Chemotherapy
- 22 August 2011
The current “state of the art” of carbapenem antibiotics and their role in the antimicrobial armamentarium are summarized and the medicinal chemist is urged to continue development of these versatile and potent compounds.
The continuing challenge of ESBLs.
Extended-spectrum cephalosporin-resistant Gram-negative organisms in livestock: an emerging problem for human health?
Intestinal Carriage of Carbapenemase-Producing Organisms: Current Status of Surveillance Methods
This review critically examines the clinical performance, advantages, and disadvantages of methods available for the detection of intestinal carriage of CPOs and suggests nucleic acid amplification techniques such as real-time PCR, hybridization assays, loop-mediated isothermal amplification (LAMP), or a combined culture and NAAT approach may provide fast results and/or added sensitivity and specificity compared with culture-based methods.
Proteus mirabilis Bloodstream Infections: Risk Factors and Treatment Outcome Related to the Expression of Extended-Spectrum β-Lactamases
- A. Endimiani, F. Luzzaro, A. Toniolo
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
- 1 July 2005
Recognition of ESBL-positive strains appears to be critical for the clinical management of patients with systemic P. mirabilis infections.
Diversity, virulence, and antimicrobial resistance of the KPC-producing Klebsiella pneumoniae ST307 clone
It is shown that the ST307 genome encodes genetic features that may provide an advantage in adaptation to the hospital environment and the human host, and acquired genetic features identified in the genome of this new emerging clone may contribute to increased persistence of ST307 in theospital environment and shed light on its potential epidemiological success.
Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA.
- A. Endimiani, A. Hujer, R. Bonomo
- Biology, MedicineThe Journal of antimicrobial chemotherapy
- 1 March 2009
The complex beta-lactamase background of KPC-Kp isolates that are emerging in multiple centres in the Eastern USA demonstrated the prevalence of a single dominant clone suggests that interstate transmission has occurred.
Emergence in Klebsiella pneumoniae and Enterobacter cloacae Clinical Isolates of the VIM-4 Metallo-β-Lactamase Encoded by a Conjugative Plasmid
- F. Luzzaro, J. Docquier, A. Toniolo
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 1 February 2004
Enterobacteria appear to increasingly contribute to the spread of VIM-type enzymes as resistance to carbapenems is an emerging problem among gram-negative hospital pathogens.
High colonization rates of extended-spectrum β-lactamase (ESBL)-producing Escherichia coliin Swiss Travellers to South Asia– a prospective observational multicentre cohort study looking at…
High colonization rates with ESBL-producing Enterobacteriaceae were found in travellers returning from South Asia, and a more common source, i.e. environmental, appears to better explain the high colonization rates.
Differentiation of IncL and IncM Plasmids Associated with the Spread of Clinically Relevant Antimicrobial Resistance
This work re-defines the structure of the IncL and IncM families and ascribes a definitive designation to the fully sequenced IncL/M plasmids available in GenBank.