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Bioactive anthraquinones from endophytic fungus Aspergillus versicolor isolated from red sea algae
The marine fungus Aspergillus versicolor was isolated from the inner tissue of the Red Sea green alga Halimeda opuntia and the biological properties of ethyl acetate extract and compounds 1–3 and 6–8 were explored for antimicrobial activity, anti-cancer activity and inhibition of Hepatitis C virus (HCV) protease.
HPLC-DAD-MS/MS profiling of phenolics from Securigera securidaca flowers and its anti-hyperglycemic and anti-hyperlipidemic activities
Securigera securidaca (L.) Degen & Doefl., Fabaceae, has been widely used in the Iranian, Indian and Egyptian folk medicine as antidiabetic and anti-hyperlipidemic remedy. Phenolic profiling of the
Isolation of Antiosteoporotic Compounds from Seeds of Sophora japonica
Histopathologically, sophoricoside ameliorated the ovarectomy induced osteoporosis in a dose dependent manner and the drug showed thicker bony trabeculae, more osteoid, and more osteoblastic rimming compared to OVX group.
New xanthones and cytotoxic constituents from Garcinia mangostana fruit hulls against human hepatocellular, breast, and colorectal cancer cell lines.
The mechanism of antiproliferative/cytotoxic effects of the tested compounds was investigated and it was found that only 5 induced significant cell cycle arrest at G0/G1-phase which is indicative of its antiprolifierative properties.
6-gingerol ameliorated doxorubicin-induced cardiotoxicity: role of nuclear factor kappa B and protein glycation
6-gingerol, a known single compound from ginger with anticancer activity, was shown to have a promising role in cardioprotection against doxorubicin-induced cardiotoxicity and might be mediated through its antioxidative effect and modulation of NF-κB as well as apoptosis.
Repurposing of Some Natural Product Isolates as SARS-COV-2 Main Protease Inhibitors via In Vitro Cell Free and Cell-Based Antiviral Assessments and Molecular Modeling Approaches
A systematic computer-aided virtual screening approach was carried out using commercially available natural products found on the Zinc Database in addition to an in-house compound library to identify potential natural product inhibitors of SARS-CoV-2 main protease (MPRO).
Saudi plants as a source of potential β-lactamase inhibitors.
Results revealed that selected plant extracts showed no antibacterial activity against tested strains; meanwhile, only Echinops viscosus, Pulicaria arabica, Tephrosia nubica, Chrozophora oblongifolia, and Clutia myricoides showed pronounced ESβL inhibitory activities.
Phenolics from Garcinia mangostana alleviate exaggerated vasoconstriction in metabolic syndrome through direct vasodilatation and nitric oxide generation
The phenolic compounds 2, 4, and 5 ameliorated the exaggerated vasoconstriction in MetS aortae through vasodilatation-NO generation mechanism.
Mangostanaxanthones III and IV: advanced glycation end-product inhibitors from the pericarp of Garcinia mangostana
All of the isolated xanthones significantly inhibited both sugar (ribose) and dicarbonyl compound (methylglyoxal)-induced protein glycation in a dose-dependent manner, explained by the ability of the isolate to inhibit protein oxidation.