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Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
Recent studies suggest that stress-induced atrophy and loss of hippocampal neurons may contribute to the pathophysiology of depression. The aim of this study was to investigate the effect ofExpand
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Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
While stressful life events are an important cause of psychopathology, most individuals exposed to adversity maintain normal psychological functioning. The molecular mechanisms underlying suchExpand
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Dynamic Contribution of Nestin-Expressing Stem Cells to Adult Neurogenesis
Understanding the fate of adult-generated neurons and the mechanisms that influence them requires consistent labeling and tracking of large numbers of stem cells. We generated aExpand
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Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a expression was regulatedExpand
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Neurobiology of Depression
Current treatments for depression are inadequate for many individuals, and progress in understanding the neurobiology of depression is slow. Several promising hypotheses of depression andExpand
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CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
The transcription factor cAMP response element (CRE)-binding protein (CREB) has been shown to regulate neural plasticity. Drugs of abuse activate CREB in the nucleus accumbens, an important part ofExpand
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Neurod1 is essential for the survival and maturation of adult-born neurons
The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell–specific deletion of Neurod1, resulting in substantially fewer newborn neuronsExpand
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Opiates inhibit neurogenesis in the adult rat hippocampus.
Recent work implicates regulation of neurogenesis as a form of plasticity in the adult rat hippocampus. Given the known effects of opiates such as morphine and heroin on hippocampal function, weExpand
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Involvement of the Lateral Hypothalamic Peptide Orexin in Morphine Dependence and Withdrawal
The lateral hypothalamus (LH) is implicated in the behavioral actions of drugs of abuse, but the cellular and molecular basis of this role is unclear. Recent identification of neuropeptides localizedExpand
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Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning
Deficiency in fragile X mental retardation protein (FMRP) results in fragile X syndrome (FXS), an inherited form of intellectual disability. Despite extensive research, it is unclear how FMRPExpand
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