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A comparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions
- E. V. van Puijenbroek, A. Bate, H. Leufkens, M. Lindquist, R. Orre, A. Egberts
- Pharmacoepidemiology and drug safety
A continuous systematic review of all combinations of drugs and suspected adverse reactions (ADRs) reported to a spontaneous reporting system, is necessary to optimize signal detection. To focus… Expand
Psychoactive substance use and the risk of motor vehicle accidents.
The driving performance is easily impaired as a consequence of the use of alcohol and/or licit and illicit drugs. However, the role of drugs other than alcohol in motor vehicle accidents has not been… Expand
Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands.
- A. Leendertse, A. Egberts, L. Stoker, P. M. van den Bemt
- Archives of internal medicine
- 22 September 2008
BACKGROUND Medication-related problems that lead to hospitalization have been the subject of many studies, many of which were limited to 1 hospital or lacked patient follow-up. Furthermore, little… Expand
The risk of cancer in users of statins.
- M. R. Graaf, A. Beiderbeck, A. Egberts, D. Richel, H. Guchelaar
- Medicine, Mathematics
- Journal of clinical oncology : official journal…
- 15 June 2004
PURPOSE Several preclinical studies suggested a role for 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) in the treatment of cancer. The objective of this study was to compare… Expand
Use of oral glucocorticoids and risk of cardiovascular and cerebrovascular disease in a population based case–control study
Objective: To assess whether use of oral glucocorticoids is associated with cardiovascular and cerebrovascular morbidity. Design and setting: Nested case–control study within a cohort of patients (⩾… Expand
Depressive Symptoms in Subjects With Diagnosed and Undiagnosed Type 2 Diabetes
Objective: To investigate if disturbed glucose homeostasis or known diagnosis of diabetes was associated with depressive symptoms. The reason for the increased prevalence of depression in patients… Expand
Association between antidepressant drug use and hyponatraemia: a case-control study.
- K. Movig, H. Leufkens, +4 authors A. Egberts
- British journal of clinical pharmacology
- 1 April 2002
AIMS To estimate the risk of, and risk factors for, hyponatraemia associated with the use of selective serotonin reuptake inhibitors (SSRIs) compared with the use of other antidepressant drugs. … Expand
The Effect of Computerized Physician Order Entry on Medication Prescription Errors and Clinical Outcome in Pediatric and Intensive Care: A Systematic Review
- F. van Rosse, B. Maat, C. Rademaker, A. J. van Vught, A. Egberts, C. Bollen
- 1 April 2009
CONTEXT. Pediatric and intensive care patients are particularly at risk for medication errors. Computerized physician order entry systems could be effective in reducing medication errors and… Expand
Use of antiepileptic drugs and risk of fractures
Objective: To study the association between use of antiepileptic drugs (AEDs) and risk of fractures. Methods: The authors obtained data from the General Practice Research Database (GPRD). A… Expand
Relationship of serotonergic antidepressants and need for blood transfusion in orthopedic surgical patients.
- K. Movig, Michiel W H E Janssen, J. de Waal Malefijt, P. Kabel, H. Leufkens, A. Egberts
- Archives of internal medicine
- 27 October 2003
BACKGROUND Several reports of various bleeding problems associated with the use of serotonergic antidepressants have been published. However, no information concerning the effect of these drugs on… Expand