A. Edge

Publications118
h-index42
Citations8,630
Highly Influential Citations342
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A promoter-level mammalian expression atlas
TLDR
It is found that few genes are truly ‘housekeeping’, whereas many mammalian promoters are composite entities composed of several closely separated TSSs, with independent cell-type-specific expression profiles.
View on Nature
Differential Distribution of Stem Cells in the Auditory and Vestibular Organs of the Inner Ear
TLDR
These findings indicate that the lack of regenerative capacity in the adult mammalian cochlea is either a result of an early postnatal loss of stem cells or diminishment of stem cell features of maturing cochlear cells.
View on Springer
Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma
View on Elsevier
Lgr5-Positive Supporting Cells Generate New Hair Cells in the Postnatal Cochlea
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Wnt-Responsive Lgr5-Expressing Stem Cells Are Hair Cell Progenitors in the Cochlea
TLDR
It is shown that Lgr5, a marker for adult stem cells, was expressed in a subset of supporting cells in the newborn and adult murine cochlea, and the responsiveness to Wnt of cells with a capacity for division and sensory cell formation suggests a potential route to new hair cell generation in the adult coChlea.
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Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti.
TLDR
The regeneration of EYFP-expressing embryonic stem cell-derived mouse neural progenitor cells shows that neurons differentiated from stem cells have the capacity to grow to a specific target in an animal model of neuronal degeneration.
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Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation.
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Central Gain Restores Auditory Processing following Near-Complete Cochlear Denervation
View on Elsevier
Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitors
TLDR
The finding suggests that Wnt/β-catenin can drive Lgr5-positive cells to act as hair cell progenitors, even after their exit from the cell cycle and apparent establishment of cell fate.
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Deglycosylation of glycoproteins with trifluoromethanesulphonic acid: elucidation of molecular structure and function.
  • A. Edge
  • Biology, Chemistry
    The Biochemical journal
  • 1 December 2003
TLDR
Glycosylated proteins from animals, plants, fungi and bacteria have been deglycosyated with TFMS, and the most extensively studied types of carbohydrate chains in mammals, the N-linked, O-linked and glycosaminoglycan chains, are all removed by this procedure.
View on PubMed
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