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Distinct Roles for FOXP3+ and FOXP3− CD4+ T Cells in Regulating Cellular Immunity to Uncomplicated and Severe Plasmodium falciparum Malaria
TLDR
While Tregs may not regulate acute malarial inflammation, they may limit memory responses to levels that subsequently facilitate parasite clearance without causing immunopathology.
Erythrocyte invasion and merozoite ligand gene expression in severe and mild Plasmodium falciparum malaria.
TLDR
expression profiles of the eba and Rh genes showed distinct clusters indicating coordinated alternative transcription, and severe and mild malaria isolates were also evenly represented across the different expression clusters.
HMOX1 Gene Promoter Alleles and High HO-1 Levels Are Associated with Severe Malaria in Gambian Children
TLDR
Mechanistic evidence that induction of HMOX1 expression in neutrophils potentiates the respiratory burst leading to oxidative damage of endothelial cells is provided, and it is proposed this may be part of the causal pathway explaining the association between short (GT)n repeats and increased disease severity in malaria and other critical illnesses.
Mother-to-Child Transmission Outcomes of HIV-Exposed Infants Followed Up in Jos North-Central Nigeria.
TLDR
In North-central Nigeria where HIV is prevalent, ART started before pregnancy is enormously effective in preventing mother-to-child transmission, and adoption of WHO 'Option B+' deserves serious consideration.
Meeting oxygen needs in Africa: an options analysis from the Gambia.
TLDR
Neither concentrators nor cylinders are well suited to every situation, but a simple options assessment can determine which is better in each setting, although ensuring a reliable supply would remain a challenge.
Malnutrition and the Intelligence Quotient of Primary School Pupils in Jos, Nigeria
TLDR
The high prevalence of under-nutrition, its association with suboptimal intelligence, as well as the detrimental role of low socio-economic class have been demonstrated in this study.
Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis
TLDR
A community-based case-control study of Gambian children was carried out to determine whether ADMA and arginine homeostasis is disrupted during severe or uncomplicated malaria infections and to test the hypothesis that DDAH1 is inactivated during Plasmodium infection.
Antituberculosis drugs and hepatotoxicity among hospitalized patients in Jos, Nigeria
TLDR
Hepatotoxicity due to first-line anti-TBs, whether based on clinical features alone or backed by liver chemistry, is common among hospitalized patients in the authors' environment and studies to determine the predictors of hepatotoxicity to guide clinical interventions aimed at the prevention or timely identification of cases are needed.
Prevalence of and risk factors for pulmonary tuberculosis among newly diagnosed HIV-1 infected Nigerian children.
TLDR
In this setting, the burden of PTB was high among newly diagnosed HIV-infected children, and late WHO HIV clinical stage and severe immunosuppression were associated with PTB-HIV co-infection.
Patterns and Predictors of First-Line Antiretroviral Therapy Modification in HIV-1-Infected Adults in a Large Urban Outpatient Cohort in Nigeria
TLDR
Modification to initial ART was common in HIV-1-infected adults on ART in Jos, Nigeria and the contribution of guideline changes on regimen modification and treatment outcomes is recommended.
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