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Eicosapolyenoic acids of serum lipids of Japanese islanders with low incidence of cardiovascular diseases.
Japanese are unique among the peoples of developed countries in having a high intake of eicosapentaenoic acid (C 20:5) from fresh fish and this may in part contribute to their low incidence ofExpand
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Role of dopamine in the regulation of blood pressure and the renin--angiotensin--aldosterone system in conscious rats.
1. In conscious rats, intracerebroventricular injection of dopamine resulted in a decrease in blood pressure, whereas injection of metoclopramide, the dopamine antagonist, produced an increase inExpand
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Dose Dependent Effect of Diltiazem on the Pharmacokinetics of Nifedipine
The effect of diltiazem pretreatment on the pharmacokinetics of nifedipine were determined in six healthy male volunteers. Placebo or diltiazem (30 mg and 90 mg) was given orally three times dailyExpand
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Clinical Pharmacology of Human Insulin of Recombinant DNA Origin in Healthy Volunteers
The serum insulin, fractional absorption, serum human C-peptide, and plasma glucose responses of normal fasting subjects were compared after the subcutaneous and intravenous administration of humanExpand
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The Effect of Diltiazem on Hepatic Drug Oxidation Assessed by Antipyrine and Trimethadione
The effect of pretreatment for 3 days with diltiazem 60 mg three times a day on the pharmacokinetics of 500‐mg antipyrine and 250‐mg trimethadione was studied in six healthy male subjects. DiltiazemExpand
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Daily variations in platelet aggregation and adhesion in healthy subjects.
Platelet aggregation is known to show a morning rise. The present study was undertaken to examine whether platelet aggregation and adhesion show a peak in the afternoon. Platelet aggregationExpand
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Clinical Pharmacology of a New Antithrombotic Agent, Ticlo
A new antithrombotic agent, ticlopidine was administered to 6 healthy volunteers to investigate its effects on platelet function and blood coagulation as well as its safety.No problem was noticed inExpand
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Comparison of the Pharmacokinetics, Pharmacodynamics, and Safety of Oral (Catapres) and Transdermal (M‐5041T) Clonidine in Healthy Subjects
The pharmacokinetic as well as pharmacodynamic properties of a transdermal clonidine, M‐5041T (M) and its safety were compared with those of oral clonidine, Catapres (Nippon Boehringer Ingelheim,Expand
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Pressor activity of renal venous effluent following constriction of renal artery in dogs.
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Pharmacodynamic and pharmacokinetic study of a slow-release formulation of furosemide in man.
A slow-release formulation of 40 mg furosemide as capsules (Eutensin) was investigated for its pharmacokinetic and pharmacodynamic properties in comparison with conventional tablets containing 40 mgExpand
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