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ALTERED RESPONSES OF AORTIC SMOOTH MUSCLE FROM SPRAGUE‐DAWLEY RATS WITH SALT‐INDUCED HYPERTENSION
TLDR
The results suggest that hypertension induced by salt‐loading is associated with enhanced sensitivity to NA, increased Ca2+ entry through receptor‐operated channels, and impairment of Na‐K ATPase enzyme activity.
Mechanism of hydralazine-induced relaxation of arterial smooth muscle.
TLDR
In the rat tail artery, hydralazine interferes with Ca2+ influx, as well as release from a membrane-bound pool, and inhibited CaCl2 and BaCl2 dose-response curves in K+-depolarised media, and depressed the phasic contractile response to N in Ca-free media.
Influence of NG-monomethyl-L-arginine on endothelium-dependent relaxations in the perfused mesenteric vascular bed of the rat.
TLDR
Data indicate that in the mesenteric arterial bed, NO formation via the L-NMMA-sensitive pathway occurs during stimulation with acetylcholine, but not under basal conditions.
Effects of calcium channel blockade in canine saphenous veins after storage at −190°C
TLDR
It is suggested that cryopreservation is a useful technique for storing venous smooth muscle for pharmacological studies and a good preservation of both contractile responsiveness and 45Ca2+ uptake mechanisms after storage at −190°C is suggested.
Barium and strontium as calcium substitutes for contractile responses in the rat tail artery.
TLDR
The ability of Ba2+ and Sr2+ to substitute for Ca2+ in contractile responses of the rat tail artery has been examined, suggesting a common mechanism for sequestration/extrusion.
Vascular smooth muscle responses in pregnancy-induced hypertension.
TLDR
Recent observations on changes within the vascular smooth muscle cell in preeclampsia as well as the effects of some vasoactive agents on critical control points within the endothelial cell suggest that local mechanisms within the blood vessel wall could play a major role.
Responses of arterial smooth muscle from normotensive and pre-eclamptic subjects to the calcium channel agonist, Bay K 8644
TLDR
The results suggest that the increased peripheral vascular sensitivity associated with pregnancy-induced hypertension may be due, at least in part, to enhanced activity of the potential-sensitive Ca2+ channels in arterial smooth muscle plasmalemma.
Role of endothelium in magnesium-induced relaxation of rat aorta
TLDR
The results suggest that Mg2+-induced relaxation of rat aorta is associated, at least in part, with the release of an endothelium-derived relaxant factor in receptor-mediated, but not in depolarisation-dependent contractions.
Mechanism of dichlorovos-induced inhibition of calcium-dependent contractions in the rat tail artery.
TLDR
The results strongly support the previous observation that dichlorovos interferes with calcium metabolism in the rat tail artery.
The Malaria-High Blood Pressure Hypothesis: Revisited.
TLDR
The state of knowledge about the malaria-high blood pressure hypothesis is presented, insights for future studies are suggested and possible mechanisms which provide justification for the hypothesis are suggested.
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