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Identification and isolation of hematopoietic stem cells.
Hematopoietic stem cells (HSCs) are defined by their ability to repopulate all of the hematopoietic lineages in vivo and sustain the production of these cells for the life span of the individual. InExpand
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Forecasting for the ordering and stock-holding of spare parts
A modern military organization like the UK's Royal Air Force is dependent on readily available spare parts for in-service aircraft in order to maximize operational capability. Expand
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Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.
A major goal of current hematopoiesis research is to develop in vitro methods suitable for the measurement and characterization of stem cells with long-term in vivo repopulating potential. PreviousExpand
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Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro.
To develop a purification strategy for isolating the most primitive hematopoietic stem cells present in normal human marrow we have combined cell separation techniques with an assay for cells thatExpand
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Enumeration of Neural Stem and Progenitor Cells in the Neural Colony‐Forming Cell Assay
Advancement in our understanding of the biology of adult stem cells and their therapeutic potential relies heavily on meaningful functional assays that can identify and measure stem cell activity inExpand
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Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.
Although hematopoiesis is known to originate in a population of very primitive cells with both lymphopoietic and myelopoietic potential, a procedure for enumerating such cells has to date not beenExpand
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Three stages of erythropoietic progenitor cell differentiation distinguished by a number of physical and biologic properties.
Previous studies have shown that erythroid precursors at sequential stages of differentiation along the red cell pathway can be distinguished by differences in the size and maturation kinetics of theExpand
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Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry.
Chronic myeloid leukemia (CML) is a clonal, multilineage myeloproliferative disorder characterized by the Philadelphia chromosome (Ph) and a marked expansion of myeloid cells. Previous studies haveExpand
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Transplantable hematopoietic stem cells in human fetal liver have a CD34(+) side population (SP)phenotype.
Cells with a verapamil-sensitive ability to efflux Hoechst 33342 (termed side population [SP] cells) have been identified in adult marrow from several species including humans and in several tissuesExpand
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Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of
It was previously shown that patients with chronic myeloid leukemia (CML) have a rare but consistently detectable population of quiescent (G0) leukemic (Philadelphia chromosome-positive andExpand
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