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Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
TLDR
A genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption among 12 population-based samples of European ancestry finds a genotype-specific expression of AUTS2 in 96 human prefrontal cortex samples and finds a regulator of alcohol consumption. Expand
αCaMKII autophosphorylation controls the establishment of alcohol-induced conditioned place preference in mice
TLDR
It is found that alcohol-induced CPP could be established at an accelerated rate in αCaMKII(T286A) compared to wild type (WT) mice, and this effect could be conditioned to the test environment and may suggest enhanced negative reinforcing action of alcohol in α CaMKII autophosphorylation deficient mice. Expand
αCaMKII controls the establishment of cocaine's reinforcing effects in mice and humans
TLDR
Investigation of the role of αCaMKII autophosphorylation in the time course of establishing cocaine use-related behavior in mice suggests that α CaMKII controls the speed for the establishment of cocaine’s reinforcing effects. Expand
RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release
TLDR
Combined animal and human data indicate a role for RASGRF2 in the regulation of mesolimbic dopamine neuron activity, reward response, and alcohol use and abuse. Expand
αCaMKII autophosphorylation controls exploratory activity to threatening novel stimuli
TLDR
The present data suggest that the behavior of αCaMKII autophosphorylation-deficient mice cannot simply be described as a low anxiety phenotype, and it is suggested that αCa MKII autophile influences locomotor reactivity to novel environments that are potentially, but not necessarily threatening. Expand
Lentiviral‐mediated gene delivery reveals distinct roles of nucleus accumbens dopamine D2 and D3 receptors in novelty‐ and light‐induced locomotor activity
TLDR
The findings suggest that D2R and D3R, expressed in the NAcc, have both shared and non‐overlapping roles in transduction of alerting signals elicited by potentially important sensory and environmental cues. Expand
GSK249320, A Monoclonal Antibody Against the Axon Outgrowth Inhibition Molecule Myelin-Associated Glycoprotein, Improves Outcome of Rodents with Experimental Stroke
TLDR
The data suggest that intravenous GSK249320 penetrates the lesion site and is associated with a small effect on functional outcomes when initiated 24 hours post-stroke and so support the translational potential of this monoclonal antibody as a restorative therapy for patients with stroke. Expand
αCaMKII Autophosphorylation Controls the Establishment of Alcohol Drinking Behavior
TLDR
The data suggest αCaMKII autophosphorylation as a facilitating mechanism in the establishment of alcohol drinking behavior with changing the DA–5-HT balance as a putative mechanism. Expand
aCaMKII Autophosphorylation Controls the Establishment of Alcohol Drinking Behavior
Correction to: Neuropsychopharmacology (2013) 38, 1636–1647; doi:10.1038/npp.2013.60 In this article, the following collaborators of The GESGA Consortium are being added to the byline: JensExpand
CAMK2A polymorphisms predict working memory performance in humans
TLDR
Genetic associations between the human CAMK2A gene and the performance in a spatial and a non-spatial working memory (non-SWM) task in two independent human samples are reported. Expand
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