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Neurotoxin-like compounds from the ichthyotoxic red tide alga Heterosigma akashiwo induce a TTX-like synaptic silencing in mammalian neurons
Abstract Heterosigma akashiwo (Raphidophyceae) is a golden-brown unicellular marine microalgae that has been implicated in massive numbers of fish deaths in natural and cultured populations around… Expand
Extracellular α‐synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane
- C. Pacheco, Camila N. Morales, +5 authors C. Opazo
- Chemistry, Medicine
- Journal of neurochemistry
- 1 March 2015
It has been postulated that the accumulation of extracellular α‐synuclein (α‐syn) might alter the neuronal membrane by formation of ‘pore‐like structures’ that will lead to alterations in ionic… Expand
Rapamycin protects against Aβ-induced synaptotoxicity by increasing presynaptic activity in hippocampal neurons.
- A. E. Ramírez, C. Pacheco, L. Aguayo, C. Opazo
- Biology, Medicine
- Biochimica et biophysica acta
- 1 September 2014
The mammalian target of rapamycin (mTOR) is involved in the regulation of learning and memory. Recently, rapamycin has been shown to be neuroprotective in models for Alzheimer's disease in an… Expand