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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
The C. elegans heterochronic gene pathway consists of a cascade of regulatory genes that are temporally controlled to specify the timing of developmental events. Mutations in heterochronic genesExpand
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A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA
The 21-nucleotide small temporal RNA (stRNA) let-7regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals. We present in vivo and in vitro evidence that inExpand
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Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing
RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves the generation of 21 to 26 nt RNA segments that guide mRNA destruction. In Caenorhabditis elegans, lin-4 andExpand
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Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
Two small RNAs regulate the timing of Caenorhabditis elegans development. Transition from the first to the second larval stage fates requires the 22-nucleotide lin-4 RNA, and transition from lateExpand
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MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship
MicroRNAs (miRNAs) have emerged as key gene regulators in diverse biological pathways. These small non-coding RNAs bind to target sequences in mRNAs, typically resulting in repressed gene expression.Expand
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Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation
MicroRNAs (miRNAs) are approximately 22 nucleotide RNAs that negatively regulate the expression of protein-coding genes. In a present model of miRNA function in animals, miRNAs that form imperfectExpand
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Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans
MicroRNAs (miRNAs) regulate gene expression by guiding Argonaute proteins to specific target mRNA sequences. Identification of bona fide miRNA target sites in animals is challenging because ofExpand
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MicroRNA silencing through RISC recruitment of eIF6
MicroRNAs (miRNAs) are a class of small RNAs that act post-transcriptionally to regulate messenger RNA stability and translation. To elucidate how miRNAs mediate their repressive effects, weExpand
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The constitutive transport element (CTE) of Mason–Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway
The constitutive transport elements (CTEs) of type D retroviruses are cis‐acting elements that promote nuclear export of incompletely spliced mRNAs. Unlike the Rev response element (RRE) of humanExpand
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MicroRNA assassins: factors that regulate the disappearance of miRNAs
MicroRNAs (miRNAs) control essential gene regulatory pathways in plants and animals. Serving as guides in silencing complexes, miRNAs direct Argonaute proteins to specific target messenger RNAs toExpand
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