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Cytotoxicity of seven naturally occurring phenolic compounds towards multi-factorial drug-resistant cancer cells.
The studied phenolics and mostly isoflavonoid 1 and lignan 4 are potential cytotoxic natural products that deserve more investigations to develop novel antineoplastic drugs against multifactorial drug-resistant cancers. Expand
Antitumor, antioxidant and antimicrobial activities of Bersama engleriana (Melianthaceae).
The overall results of this study indicates that the extracts from the roots, stem bark, leaves and wood have interesting antioxidant properties and represent a potential source of medicine for the treatment of infectious diseases and cancer. Expand
Antibacterial activity of selected Cameroonian dietary spices ethno-medically used against strains of Mycobacterium tuberculosis.
The results of this study suggest that Echinops giganteus and Piper guineense could be important sources of bactericidal compounds against M. tuberculosis and could probably be promising candidates that can be further investigated. Expand
Evaluation of four Cameroonian medicinal plants for anticancer, antigonorrheal and antireverse transcriptase activities.
Methanol extracts from the leaves, bark and roots of four Cameroonian medicinal plants were tested for their in vitro cytotoxicity, antigonorrheal and antireverse transcriptase activities and showed that all extracts contained compounds belonging to the classes of phenols and terpenoids. Expand
Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (neobavaisoflavone, sigmoidin H and isoneorautenol) toward multi-factorial drug resistant cancer cells.
The cytotoxicity of the studied isoflavonoids and especially the pterocarpan 3 deserve more detailed exploration in the future to develop novel anticancer drugs against sensitive and otherwise drug-resistant phenotypes. Expand
Anti-inflammatory and anti-hyaluronate lyase activities of lanostanoids from Piptoporus betulinus.
promising anti-inflammatory agents by inhibiting 3αhydroxysteroid dehydrogenase. 1-4 also possess a remarkable selective activity towards bacterial hyaluronate lyase while not affecting bovineExpand
Cytotoxicity of a naturally occurring furoquinoline alkaloid and four acridone alkaloids towards multi-factorial drug-resistant cancer cells.
The five tested alkaloids and mostly acridone 5 are potential cytotoxic natural products that deserve more investigations to develop novel cytotoxicity compounds against multifactorial drug-resistant cancers. Expand
Antibacterial constituents of three Cameroonian medicinal plants: Garcinia nobilis, Oricia suaveolens and Balsamocitrus camerunensis
The results of the present investigation provide evidence that the crude extract from G. nobilis, O. suaveolens and B. camerunensis as well as some of their compounds, and mostly compound 2 (isolated from the most active extract GNB), could be considered as interesting natural antibacterial products. Expand
Heterocycles of biological importance. Part 5. The formation of novel biologically active pyrimido[1,2-a]benzimidazoles from allenic nitriles and aminobenzimidazoles
The reaction of allenic nitriles with 2-aminobenzimidazoles gives 2-aminopyrimido[1,2-a]benzimidazoles 5 in very good yields. The pharmacological screening of compound 5a, 5d and 5i shows that theyExpand
Antioxidant, antitumor and antimicrobial activities of the crude extract and compounds of the root bark of Allanblackia floribunda
The overall results of the present work provide baseline information for the potential use of the root bark extract of A. floribunda as an antimicrobial, antitumor and antioxidant phytomedicine. Expand