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Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety ofExpand
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
T tumors have "borrowed" fundamental mechanisms that developed in multicellular organisms for purposes of tissue defense, renewal, and repair and taught us something new about angiogenesis, namely, that vascular hyperpermeability and consequent plasma protein extravasation are important, perhaps essential, elements in its generation. Expand
ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.
It is found that elevated intercellular adhesion molecule-1 (ICAM-1) expression regulates the location of polymorphonuclear leukocyte (PMN) TEM and promotes junctional and nonjunctional TEM across inflamed vascular endothelium via distinct cytoplasmic tail associations. Expand
Transcellular diapedesis is initiated by invasive podosomes.
It is demonstrated that lymphocytes usedpodosomes and extended "invasive podosomes" to palpate the surface of, and ultimately form transcellular pores through, the endothelium, providing insights into basic mechanisms for leukocyte trafficking and the functions of podosome. Expand
Vascular permeability, vascular hyperpermeability and angiogenesis
It is demonstrated that three distinctly different types of vascular permeability can be distinguished, based on the differenttypes of microvessels involved, the composition of the extravasate, and the anatomic pathways by which molecules of different size cross-vascular endothelium mediate. Expand
Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis.
New insights into the mechanisms of angiogenesis and stroma formation are provided, insights which are potentially applicable to a wide variety of disease states and which may lead to identification of new targets for therapeutic intervention. Expand
T1α/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema
Data identify T1α/podoplanin as a novel critical player that regulates different key aspects of lymphatic vasculature formation as well as small interfering RNA‐mediated inhibition of T1 α/Podoplanin expression decreased lymphatic endothelial cell adhesion. Expand
Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor
The muscular vessels that developed from mother vessels in skin and perimuscle fat have the structure of collaterals and could be useful clinically in the relief of tissue ischemia and indicate that the angiogenic response induced by VPF/VEGF is heterogeneous and tissue specific. Expand
Vascular permeability factor (VPF, VEGF) in tumor biology
VPF/VEGF has recently been found to have a role in wound healing and its expression by activated macrophages suggests that it probably also participates in certain types of chronic inflammation. Expand
Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies
The presence of ribosomes, ER‐like membranes and many membrane‐associated and ER luminal proteins within LBs, supports a new model by which enveloped ER‐membranes and domains form LBs and indicates that LBs may be sites of protein synthesis. Expand