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Mining α-Helix-Forming Molecular Recognition Features with Cross Species Sequence Alignments†
Previously described algorithms for mining alpha-helix-forming molecular recognition elements (MoREs), described by Oldfield et al. (Oldfield, C. J., Cheng, Y., Cortese, M. S., Brown, C. J., Uversky,Expand
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Introduction to intrinsically disordered proteins and regions
Abstract Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are fascinating dynamic conformational ensembles that are observed under physiological conditions. TheyExpand
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A Novel Strategy for the Development of Vaccines for SARS-CoV-2 (COVID-19) and Other Viruses Using AI and Viral Shell Disorder
A model that predicts levels of coronavirus (CoV) respiratory and fecal–oral transmission potentials based on the shell disorder has been built using neural network (artificial intelligence, AI)Expand
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Disorder to Order, Nonlife to Life: In the Beginning There Was a Mistake
Living matter is solemnly perceived as an embodiment of ultimate order that neither centuries long studies nor imagination can fully grasp. Yet, disorder is its necessary component in an intricateExpand
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Do Viral Proteins Possess Unique Features
Many proteins (or protein regions) are intrinsically disordered. They lack unique 3D structures in their native, functional states under physiological conditions in vitro (Wright and Dyson, 1999;Expand
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On the Importance of Computational Biology and Bioinformatics to the Origins and Rapid Progression of the Intrinsically Disordered Proteins Field
The concept that an unfolded protein could have biological function was proposed by Linus Pauling in 1940. The first experimental evidence for the existence of unfolded proteins, which are now oftenExpand