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Atrial fibrillation and risk of clinical events in chronic heart failure with and without left ventricular systolic dysfunction: results from the Candesartan in Heart failure-Assessment of Reduction…
Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction.
It is concluded that targeted deletion of the MMP9 gene attenuates LV dilation after experimental MI in mice and the decrease in collagen accumulation and the enhanced expression of other MMPs suggest that MMP-9 plays a prominent role in extracellular matrix remodeling after MI.
Rhythm control versus rate control for atrial fibrillation and heart failure.
In patients with atrial fibrillation and congestive heart failure, a routine strategy of rhythm control does not reduce the rate of death from cardiovascular causes, as compared with a rate-control strategy.
Enalapril Decreases the Incidence of Atrial Fibrillation in Patients With Left Ventricular Dysfunction Insight From the Studies Of Left Ventricular Dysfunction (SOLVD) Trials
Treatment with the ACEi enalapril markedly reduces the risk of development of atrial fibrillation in patients with left ventricular dysfunction.
Transmural action potential and ionic current remodeling in ventricles of failing canine hearts.
- Gui-Rong Li, C. Lau, A. Ducharme, J. Tardif, S. Nattel
- Biology, MedicineAmerican journal of physiology. Heart and…
- 1 September 2002
It is indicated that HF remodels electrophysiology in all layers of the left ventricle, and the downregulation of I(K1), I(to1), and I(ks) increases APD and favors occurrence of EADs.
Cystatin C deficiency in human atherosclerosis and aortic aneurysms.
It is shown that, whereas cystatin C is normally expressed in vascular wall smooth muscle cells (SMCs), this cysteine protease inhibitor is severely reduced in both atherosclerotic and aneurysmal aortic lesions and it is established that cyStatin C deficiency occurs in vascular disease.
Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice.
Administration of an MMP inhibitor attenuates early left ventricular dilation after experimental MI in mice, and the effects of MMP inhibition on the changes in end-systolic area and end-diastolic area were most prominent in animals that had more initialleft ventricular dilatation.
Prevention of atrial fibrillation in patients with symptomatic chronic heart failure by candesartan in the Candesartan in Heart failure: assessment of Reduction in Mortality and morbidity (CHARM)…
Impact of care at a multidisciplinary congestive heart failure clinic: a randomized trial
- A. Ducharme, O. Doyon, M. White, J. Rouleau, J. Brophy
- MedicineCanadian Medical Association Journal
- 5 July 2005
Care at a multidisciplinary specialized outpatient congestive heart failure outpatient clinic reduced the number of hospital readmissions and hospital days and improved quality of life, when integrated with those from other, similar trials.
Enalapril Reduces the Incidence of Diabetes in Patients With Chronic Heart Failure: Insight From the Studies Of Left Ventricular Dysfunction (SOLVD)
Enalapril significantly reduces the incidence of diabetes in patients with left ventricular dysfunction, especially those with impaired FPG.