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Incidence of adenocarcinoma among patients with Barrett's esophagus.
BACKGROUND Accurate population-based data are needed on the incidence of esophageal adenocarcinoma and high-grade dysplasia among patients with Barrett's esophagus. METHODS We conducted aExpand
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McGill Pain Questionnaire Translated into Danish: Experimental and Clinical Findings
Objective:To develop a methodology for translating the McGill Pain Questionaire (MPQ) into a Danish version, and to make comparisons to studies of patients speaking other languages. Design:FindingExpand
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Recommendations on practice of conditioned pain modulation (CPM) testing
Protocols for testing conditioned pain modulation (CPM) vary between different labs/clinics. In order to promote research and clinical application of this tool, we summarize the recommendations ofExpand
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Experimental human pain models: a review of standardised methods for preclinical testing of analgesics.
Treatment of pain is one of the major challenges in clinical medicine. However, it is often difficult to evaluate the effect of a treatment, as the many symptoms of the underlying diseases oftenExpand
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Opioid-Induced Bowel Dysfunction
Opioids are the most commonly prescribed medications to treat severe pain in the Western world. It has been estimated that up to 90% of American patients presenting to specialized pain centres areExpand
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Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain
Aliment Pharmacol Ther 2011; 33: 1113–1122
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Human Experimental Pain Models for Assessing the Therapeutic Efficacy of Analgesic Drugs
Pain models in animals have shown low predictivity for analgesic efficacy in humans, and clinical studies are often very confounded, blurring the evaluation. Human experimental pain models mayExpand
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Sleep in rheumatoid arthritis: a comparison with healthy subjects and studies of sleep/wake interactions.
Sleep complaints are frequent in patients with rheumatoid arthritis (RA) and sleep disturbances may contribute to pain and other daytime complaints. The aims of the current study were to compareExpand
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Tapentadol potentiates descending pain inhibition in chronic pain patients with diabetic polyneuropathy.
BACKGROUND Tapentadol is an analgesic agent for treatment of acute and chronic pain that activates the µ-opioid receptor combined with inhibition of neuronal norepinephrine reuptake. Both mechanismsExpand
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Experimental human muscle pain and muscular hyperalgesia induced by combinations of serotonin and bradykinin
In the present study, we assessed the muscle pain and possible development of muscular hyperalgesia to mechanical stimuli after two subsequent intramuscular infusions of serotonin (5-HT) andExpand
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