• Publications
  • Influence
Proenkephalin A gene products activate a new family of sensory neuron–specific GPCRs
Several peptide fragments are produced by proteolytic cleavage of the opioid peptide precursor proenkephalin A, and among these are a number of enkephalin fragments, in particular bovine adrenalExpand
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Bradykinin and inflammatory pain
There is compelling evidence linking bradykinin (BK) with the pathophysiological processes that accompany tissue damage and inflammation, especially the production of pain and hyperalgesia. SeveralExpand
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Kinins and kinin receptors in the nervous system
Kinins, including bradykinin and kallidin, are peptides that are produced and act at the site of tissue injury or inflammation. They induce a variety of effects via the activation of specific B1 orExpand
  • 199
  • 8
Kinins and their receptors in hyperalgesia.
  • A. Dray
  • Chemistry, Medicine
  • Canadian journal of physiology and pharmacology
  • 1 June 1997
Kinins (bradykinin, kallidin) are produced at sites of injury and inflammation and serve a critical role in signaling tissue distress as well as organising tissue responsiveness to injury. The acuteExpand
  • 129
  • 8
Arthritis and pain. Future targets to control osteoarthritis pain
Clinical presentation of osteoarthritis (OA) is dominated by pain during joint use and at rest. OA pain is caused by aberrant functioning of a pathologically altered nervous system with keyExpand
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Antinociceptive activity of the bradykinin B1 and B2 receptor antagonists, des-Arg9, [Leu8]-BK and HOE 140, in two models of persistent hyperalgesia in the rat
&NA; There has been recent evidence linking bradykinin (BK) receptors with inflammation. This study has investigated the involvement of BK receptors in two models of persistent inflammatoryExpand
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Neuropathic pain: emerging treatments.
  • A. Dray
  • Medicine
  • British journal of anaesthesia
  • 1 July 2008
Neuropathic pain remains one of the most challenging of all neurological diseases and presents a large unmet need for improved therapies. Many mechanistic details are still lacking, but greaterExpand
  • 150
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Chemical activation of nociceptive peripheral neurones.
In inflammation, non-neuronal cells produce a variety of chemical mediators that act on nociceptive neurones. Ultimately, the discharge of these neurones is controlled by the activity of membrane ionExpand
  • 203
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Serotonin in the basal ganglia: functions and interactions with other neuronal pathways.
  • A. Dray
  • Medicine, Biology
  • Journal de physiologie
  • 1981
The serotoninergic innervation of the striatum and substantia nigra has been confirmed by a number of techniques. Inputs to both these regions appear to be inhibitory, but the possibility ofExpand
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A pro-nociceptive role of neuromedin U in adult mice
Although the neuropeptide neuromedin U (NMU) was first isolated from the spinal cord, its actions in this site are unknown. The recent identification of the NMU receptor subtype 2 (NMU2R) in theExpand
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