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A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls, and we found that a previously described variant in the transcription factor 7-like 2 geneExpand
A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans
TLDR
The findings suggests that, in addition to or in lieu of relying solely on replicated variants of moderate-to-large effect reaching genome-wide significance, pathway and network approaches may be useful in identifying and prioritizing candidate genes/loci for further experiments. Expand
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
TLDR
Another variant of the TCF7L2 type 2 diabetes risk variant, HapBT2D, is identified that shows evidence of positive selection in East Asian, European and West African populations, indicating that the selective advantage of HapA may have been mediated through effects on energy metabolism. Expand
The African Genome Variation Project shapes medical genetics in Africa
TLDR
It is shown that modern imputation panels (sets of reference genotypes from which unobserved or missing genotypes in study sets can be inferred) can identify association signals at highly differentiated loci across populations in sub-Saharan Africa. Expand
Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk
TLDR
A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention. Expand
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
TLDR
Examination of genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolicBlood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs supports the notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity. Expand
Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes
TLDR
A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies. Expand
Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
TLDR
It is demonstrated that SLC16A11 is a proton-coupled monocarboxylate transporter and that genetic perturbation of SLC15A11 induces changes in fatty acid and lipid metabolism that are associated with increased T2D risk, and suggested that increasing SLC 16A11 function could be therapeutically beneficial for T1D. Expand
Evolution of the primate trypanolytic factor APOL1
TLDR
This study shows that both genetic variants of human APOL1 that protect against T. brucei rhodesiense have recapitulated molecular signatures found in Old World monkeys and raises the possibility that APol1 variants have broader innate immune activity that extends beyond trypanosomes. Expand
FTO Genetic Variation and Association With Obesity in West Africans and African Americans
TLDR
The FTO gene shows significant differences in allele frequency and LD patterns in populations of African ancestry compared with other continental populations, as well as evidence of heterogeneity in association. Expand
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