A. Douglas Kinghorn
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The induction of the phase II drug-metabolizing enzyme, NAD(P)H:quinone reductase (QR), using Hepa 1c1c7 hepatoma cells, is currently used as a key member of a panel of in vitro bioassays in our… Continue Reading
Abstract. Purpose: To study the pharmacokinetics of deguelin, a naturally occurring potential cancer chemopreventive agent, in rats. Methods: [3H]Deguelin was administered intravenously (i.v.) under… Continue Reading
As a result of a bioactivity-guided search for novel, plant-derived cancer chemopreventive agents, ixocarpalactone A (5) was isolated previously as a potent quinone reductase inducer from the leaves… Continue Reading