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Cytotoxic lignans from Larrea tridentata.
Six lignans, including the cyclolignan 3,4'-dihydroxy-3',4'-dimethoxy-6,7'-cyclolignan, were isolated from the flowering tops of Larrea tridentata. Additionally the flavanone,… Expand
Total synthesis and bioactivity of 18(R)-hydroxyeicosapentaenoic acid.
- Venkata R Krishnamurthy, A. Dougherty, C. Haller, E. Chaikof
- Medicine, Chemistry
- The Journal of organic chemistry
- 2 June 2011
Resolvins are family of lipid mediators derived from omega-3 polyunsaturated fatty acids, which are generated during the resolution phase of acute inflammation. Resolvin E1 is biosynthesized from… Expand
Synthesis of an Fmoc-threonine bearing core-2 glycan: a building block for PSGL-1 via Fmoc-assisted solid-phase peptide synthesis.
- Venkata R Krishnamurthy, A. Dougherty, M. Kamat, Xuezheng Song, R. Cummings, E. Chaikof
- Chemistry, Medicine
- Carbohydrate research
- 19 July 2010
Selectins (L, E, and P) are vascular endothelial molecules that play an important role in the recruitment of leukocytes to inflamed tissue. In this regard, P-Selectin glycoprotein-1 (PSGL-1) has been… Expand
Synthesis of 1-deoxysphingosine derivatives with conformationally restricted pyrrolidinediol head groups.
[structure: see text] A family of cyclic 1-deoxysphingolipid derivatives of structure 4 has been designed and synthesized, which may serve as tumorigenesis suppressors for various cancers. Compound 4… Expand