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Mutant cystic fibrosis transmembrane conductance regulator inhibits acidification and apoptosis in C127 cells: possible relevance to cystic fibrosis.
We have shown elsewhere that acidification is an early event in apoptosis, preceding DNA cleavage. Cells expressing the most common mutation (delF508) of the cystic fibrosis transmembrane regulatorExpand
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The bronchoalveolar lavage fluid of cystic fibrosis lung transplant recipients demonstrates increased interleukin-8 and elastase and decreased IL-10.
Cystic fibrosis (CF) patients continue to have reservoirs of Pseudomonas aeruginosa infection in their sinuses and trachea after transplantation, and studies indicate that nontransplanted CF patientsExpand
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Coccidioidomycosis and Lung Transplantation
Coccidioidomycosis, an endemic fungal infection in the desert southwestern United States, causes substantial morbidity and mortality in immunocompromised hosts. Because lungs are the primary site ofExpand
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Respiratory syncytial virus augments production of fibroblast growth factor basic in vitro: Implications for a possible mechanism of prolonged wheezing after infection
Respiratory syncytial virus (RSV) has been linked to the development of clinical asthma. Cellular mechanisms of this observation are not yet clearly elucidated. In chronic asthma, production ofExpand
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Genomic meta-analysis of growth factor and integrin pathways in chronic kidney transplant injury
BackgroundChronic Allograft Nephropathy (CAN) is a clinical entity of progressive kidney transplant injury. The defining histology is tubular atrophy with interstitial fibrosis (IFTA). Using aExpand
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Respiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction
  • A. Dosanjh
  • Medicine
  • Journal of inflammation research
  • 19 March 2015
Background Metapneumoviral respiratory infection is a community-acquired respiratory viral (CARV) infection. Lung transplantation recipients exposed to CARV are at risk for development of allograftExpand
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Liquid ventilation provides uniform distribution of perfluorocarbon in the setting of respiratory failure.
BACKGROUND We evaluated the effect of perfluorocarbon liquid ventilation (LV) on gas exchange and pulmonary function in the setting of respiratory failure and the distribution of the ventilatingExpand
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Heterologous expression of delta F508 CFTR results in decreased sialylation of membrane glycoconjugates.
The cystic fibrosis transmembrane conductance regulator (CFTR) is commonly mutated in cystic fibrosis to the delta F508 CFTR. CFTR has been shown to function as a adenosine 3',5'-cyclicExpand
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A comparison of microbiologic flora of the sinuses and airway among cystic fibrosis patients with maxillary antrostomies
Abstract: The placement of maxillary antrostomies among cystic fibrosis (CF) patients has been used as a treatment to allow localized antibiotic lavage of infected sinus passages. This procedure isExpand
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Divergent effects of extracellular oxygen on the growth, morphology, and function of human skin microvascular endothelial cells
Partial pressure of extracellular oxygen influences a number of major cellular functions. The purpose of this study was to determine if the proliferation, morphology, and synthesis of proteinsExpand
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