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Artemisinin resistance in Plasmodium falciparum malaria.
P. falciparum has reduced in vivo susceptibility to artesunate in western Cambodia as compared with northwestern Thailand, and resistance is characterized by slow parasite clearance in vivo without corresponding reductions on conventional in vitro susceptibility testing.
Spread of artemisinin resistance in Plasmodium falciparum malaria.
Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.
Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria
Biochemical and cellular evidence is provided that artemisinins are potent inhibitors of Plasmodium falciparum phosphatidylinositol-3-kinase (PfPI3K), revealing an unexpected mechanism of action and present PI3P as the key mediator of art Artemisinin resistance and the sole PfPI3k as an important target for malaria elimination.
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
An analysis of genome variation in 825 P. falciparum samples from Asia and Africa is described that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia, and a catalog of SNPs that show high levels of differentiation in the art Artemisinin-resistant subpopulations are provided.
Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia.
- Shannon Takala-Harrison, Christopher G. Jacob, C. Plowe
- Biology, MedicineThe Journal of infectious diseases
- 1 March 2015
While there was some evidence of spreading resistance, there was no evidence of resistance moving westward from Cambodia into Myanmar, and K13 appears to be a major determinant of artemisinin resistance throughout Southeast Asia.
Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker