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Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.
TLDR
Evidence is provided of a selective role for CCK-B receptors in the control of anxiety in mice previously made tolerant to diazepam and members of a class of anxiolytic agents that have a greatly improved profile compared with benzodiazepines or serotonin-related anxIOlytics. Expand
Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome
TLDR
The data demonstrate that rearing rats in grid-floor cages represents a form of chronic mild stress associated with increased corticosterone levels, decreased basal turnover of entorhinal dopamine and increased dopamine activity in the left nucleus accumbens and support the contention that there is a link between social isolation, attention deficit, spontaneous locomotor hyperactivity and reduced dopamine turnover in the medial prefrontal cortex. Expand
Effects of the 5‐HT3 receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain
TLDR
It is concluded that the 5‐HT3 receptor antagonist GR38032F, and the neuroleptic agents fluphenazine, sulpiride and haloperidol, can reduce raised mesolimbic dopaminergic activity in the rat and marmoset. Expand
Zacopride: anxiolytic profile in rodent and primate models of anxiety
TLDR
It is concluded that the 5‐HT3 receptor antagonist, zacopride, alters rodent and primate behaviour in a manner consistent with that of an anxiolytic agent. Expand
Differential Effects of Prenatal Stress in Two Inbred Strains of Rats
TLDR
It is suggested that prenatal stress exerts long-term effects on behavior, which depend on the genetic background, including birth weights, pain thresholds, and basal and stress-induced corticosterone secretion. Expand
The Disruption of Prepulse Inhibition by Social Isolation in the Wistar Rat: How Robust Is the Effect?
TLDR
Investigation of isolation-induced disruptions of the prepulse inhibition (PPI) response in the Wistar rat strain, as a function of exposure of the animals to locomotor activity testing found disruptions obtained to be consistent across all pulse frequencies examined and independent of effects on startle. Expand
Early social isolation, but not maternal separation, affects behavioral sensitization to amphetamine in male and female adult rats
TLDR
The present results suggest that a postweaning manipulation of the environment (SI) is more effective than a pre weaning manipulation (MS) in modifying the expression of sensitization to amphetamine. Expand
The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates
TLDR
It is concluded that ondansetron potently improves basal performance in rodent and primate tests of cognition and inhibits the impairments in performance caused by cholinergic deficits. Expand
Strain differences in the isolation-induced effects on prepulse inhibition of the acoustic startle response and on locomotor activity.
TLDR
Strain differences in the different parameters measured did not predict isolation-induced effects on PPI, but sensitivity to the drug differed, with WS and SD rats being more sensitive to lower doses than LH rats. Expand
Dissociation between the effects of pre-weaning and/or post-weaning social isolation on prepulse inhibition and latent inhibition in adult Sprague–Dawley rats
TLDR
The results support the contention that both PPI and LI assess processes of selective attention and that they involve differing neuro-psychological mechanisms and could represent a relevant animal model for some aspects of schizophrenia. Expand
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