Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.
- J. Hughes, P. Boden, G. Woodruff
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 1 September 1990
Evidence is provided of a selective role for CCK-B receptors in the control of anxiety in mice previously made tolerant to diazepam and members of a class of anxiolytic agents that have a greatly improved profile compared with benzodiazepines or serotonin-related anxIOlytics.
Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome
- C. Heidbreder, I. Weiss, P. Nelson
- Biology, PsychologyNeuroscience
- 11 October 2000
Effects of the 5‐HT3 receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain
- B. Costall, A. Domeney, R. Naylor, M. Tyers
- Biology, PsychologyBritish Journal of Pharmacology
- 1 December 1987
It is concluded that the 5‐HT3 receptor antagonist GR38032F, and the neuroleptic agents fluphenazine, sulpiride and haloperidol, can reduce raised mesolimbic dopaminergic activity in the rat and marmoset.
Zacopride: anxiolytic profile in rodent and primate models of anxiety
- B. Costall, A. Domeney, P. Gerrard, M. Kelly, R. Naylor
- Psychology, BiologyThe Journal of pharmacy and pharmacology
- 1 April 1988
It is concluded that the 5‐HT3 receptor antagonist, zacopride, alters rodent and primate behaviour in a manner consistent with that of an anxiolytic agent.
The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates
- J. Barnes, B. Costall, M. Tyers
- Biology, PsychologyPharmacology, Biochemistry and Behavior
- 1 April 1990
Strain differences in the isolation-induced effects on prepulse inhibition of the acoustic startle response and on locomotor activity.
- I. Weiss, L. Di Iorio, J. Feldon, A. Domeney
- Biology, PsychologyBehavioral Neuroscience
- 1 April 2000
Strain differences in the different parameters measured did not predict isolation-induced effects on PPI, but sensitivity to the drug differed, with WS and SD rats being more sensitive to lower doses than LH rats.
The Disruption of Prepulse Inhibition by Social Isolation in the Wistar Rat: How Robust Is the Effect?
- A. Domeney, J. Feldon
- Psychology, BiologyPharmacology, Biochemistry and Behavior
- 1 April 1998
Differential Effects of Prenatal Stress in Two Inbred Strains of Rats
- T. Stöhr, D. Wermeling, J. Feldon
- Psychology, BiologyPharmacology, Biochemistry and Behavior
- 1 April 1998
Dissociation between the effects of pre-weaning and/or post-weaning social isolation on prepulse inhibition and latent inhibition in adult Sprague–Dawley rats
- I. Weiss, A. Domeney, J. Moreau, H. Russig, J. Feldon
- Psychology, BiologyBehavioural Brain Research
- 1 June 2001
Early social isolation, but not maternal separation, affects behavioral sensitization to amphetamine in male and female adult rats
- I. Weiss, A. Domeney, C. Heidbreder, J. Moreau, J. Feldon
- Psychology, BiologyPharmacology, Biochemistry and Behavior
- 1 October 2001
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