• Publications
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The role of excitotoxicity in neurodegenerative disease: implications for therapy.
  • A. Doble
  • Biology, Medicine
  • Pharmacology & therapeutics
  • 1 March 1999
Glutamic acid is the principal excitatory neurotransmitter in the mammalian central nervous system. Glutamic acid binds to a variety of excitatory amino acid receptors, which are ligand-gated ionExpand
  • 691
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Benefit of vitamin E, riluzole, and gababapentin in a transgenic model of familial amyotrophic lateral sclerosis
Familial amyotrophic lateral sclerosis (FALS) has been linked in some families to dominant mutations of the SOD1 gene encoding Cu,Zn superoxide dismutase (Cu,Zn SOD). We have used a transgenic modelExpand
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  • 25
The pharmacology and mechanism of action of riluzole
  • A. Doble
  • Chemistry, Medicine
  • Neurology
  • 1 December 1996
The excitotoxic hypothesis of neurodegeneration has stimulated much interest in the possibility of using compounds that will block excitotoxic processes to treat neurologic disorders.Riluzole is aExpand
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Possible involvement of nitric oxide in long-term potentiation.
Long-term potentiation (LTP) in the hippocampus is known to involve NMDA (N-methyl-D-aspartate) receptors. Since activation of NMDA receptors in the cerebellum results in the formation of nitricExpand
  • 629
  • 13
(–)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor
The existence of a receptor for γ-aminobutyric acid (GABA) on neurones of the mammalian central nervous system (CNS) is now firmly established1–3. It is generally accepted that bicuculline (and itsExpand
  • 1,036
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Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats.
Nitric oxide (NO) is a messenger molecule that is produced in the brain from the metabolism of L-arginine to L-citrulline. Growing evidence suggests a physiological role for NO in long-termExpand
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Bicuculline-insensitive GABA receptors on peripheral autonomic nerve terminals.
The action of gamma-aminobutyric acid (GABA) and related compounds on rat isolated atria and mouse and guinea pig isolated vas deferens has been studied. GABA depressed the evoked but not basalExpand
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Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes.
The effects of riluzole, an anticonvulsant and neuroprotective compound, on excitatory amino acid-evoked currents were studied in Xenopus laevis oocytes injected with mRNA from rat whole brain orExpand
  • 185
  • 5
Labelling of peripheral-type benzodiazepine binding sites in human brain with [3H]PK 11195: Anatomical and subcellular distribution
The peripheral-type benzodiazepine binding site, erstwhile characterized in the rodent and feline brain, has now been characterized in post-mortem human brain using [3H]PK 11195. The kinetics andExpand
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  • 5
Therapeutic advances in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is a progressive and rapidly fatal neurodegenerative disease in which both upper and lower motoneurones are involved. The recent discovery of mutations affectingExpand
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