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Environmental Complexity and Social Organization Sculpt the Brain in Lake Tanganyikan Cichlid Fish
TLDR
It is found that environmental and social factors differentially affect the brain, with environmental factors showing a broader effect on a range of brain structures compared to social factors. Expand
Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma.
TLDR
It is demonstrated that increased IOP leads to the initiation of a CaN-mediated mitochondrial apoptotic pathway in glaucoma and support neuroprotective strategies for this blinding disease. Expand
Visual acuity, environmental complexity, and social organization in African cichlid fishes.
TLDR
The authors' results are the first to demonstrate that species-specific differences in visual acuity are associated with differences in both the physical and social environment. Expand
Transcriptional up-regulation and activation of initiating caspases in experimental glaucoma.
TLDR
The data suggest that elevated IOP activates a transcriptional up-regulation and activation of initiating caspases in RGCs and triggers apoptosis through both extrinsic and intrinsic caspase cascades. Expand
Quantifying habitat complexity in aquatic ecosystems
Summary 1. Many aquatic studies have attempted to relate biological features, such as species diversity, abundance, brain size and behaviour, to measures of habitat complexity. Previous measures ofExpand
Hsp27 phosphorylation in experimental glaucoma.
TLDR
These results confirm previous reports of elevated Hsp27 in experimental glaucoma and extend them to the DBA/2J mouse, suggesting that glial cells contribute to the increase in Hsp 27 and pHsp27 seen in experimentalglaucomA. Expand
Predictability and limitations of non-invasive murine tonometry: comparison of two devices.
TLDR
Evaluating the accuracy, reproducibility and predictive ability of two non-invasive tonometers developed for intraocular pressure measurements in the mouse found both provide accurate and reproducible measurements with the OIT requiring calibration curves for each individual investigator. Expand
Efficient estimation of retinal ganglion cell number: A stereological approach
TLDR
It is empirically demonstrated that only approximately 1:20 sections need be assessed to accurately estimate the total number of RGCs in the rat retina, providing ample tissue for additional studies in the same retina and saving considerably on more exhaustive sampling strategies. Expand
FK506 blocks activation of the intrinsic caspase cascade after optic nerve crush.
TLDR
The data suggest that caspase 9 activation may play an important role in retinal ganglion cell death following optic nerve crush and that the neuroprotection seen with FK506 may be mediated by interfering with the activation of caspases 9. Expand
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