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A multisensory investigation of the functional significance of the “pain matrix”
TLDR
FMRI responses triggered by nociceptive stimuli can be largely explained by a combination of multimodal neural activities and somatosensory-specific but not nocICEptive-specific neural activities. Expand
Slow EEG pattern predicts reduced intrinsic functional connectivity in the default mode network: An inter-subject analysis
TLDR
A network and frequency specific relation between RSN FC and EEG is demonstrated, which validates the biological relevance of network-specific intrinsic FC and provides an initial neurophysiological basis for interpreting studies of DMN FC alterations. Expand
Pulsed arterial spin labeling perfusion imaging at 3 T: estimating the number of subjects required in common designs of clinical trials.
TLDR
Pulsed arterial spin labeling (PASL) is an increasingly common technique for noninvasively measuring cerebral blood flow and has previously been shown to have good repeatability, and comparatively small cohorts are adequate for detecting regional changes in CBF in common types of clinical trial design. Expand
The Thalamus and Brainstem Act As Key Hubs in Alterations of Human Brain Network Connectivity Induced by Mild Propofol Sedation
TLDR
The effects of propofol, at a dose that produced mild sedation without loss of consciousness, on spontaneous cerebral activity of 15 healthy volunteers using functional magnetic resonance imaging (fMRI), exploiting oscillations in blood oxygenation level-dependent signal across functionally connected brain regions is investigated. Expand
Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation
TLDR
It is demonstrated, that propofol-induced sedation is accompanied by increased stimulus-induced gamma activity providing a potential window into mechanisms of gamma-oscillation generation in humans. Expand
Separating neural and vascular effects of caffeine using simultaneous EEG–FMRI: Differential effects of caffeine on cognitive and sensorimotor brain responses
TLDR
The combined use of EEG-FMRI was able to identify vascular effects and hence altered neurovascular coupling through the alteration of low-level task FMRI responses in the face of a preserved visual evoked potential and suggest a cognitive effect of caffeine through its positive effect on the frontal BOLD signal consistent with the shortening of oddball EEG response latency. Expand
Storm in a coffee cup: caffeine modifies brain activation to social signals of threat.
TLDR
Results showed that caffeine induced threat-related (angry/fearful faces > happy faces) midbrain-periaqueductal gray activation and abolishedthreat-related medial prefrontal cortex wall activation, and implicate the amygdala as a key site for caffeine tolerance. Expand
Extracting drug mechanism and pharmacodynamic information from clinical electroencephalographic data using generalised semi-linear canonical correlation analysis.
TLDR
The extension to human EEG data of a generalised semi-linear canonical correlation analysis (GSLCCA), developed for small animal data, is described, confirming that GSLCCA can be successfully applied to clinical EEG data. Expand
Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study
TLDR
This cerebral perfusion study demonstrates that propofol induces suppression of key cortical (frontal lobe) and subcortical (thalamus) regions during mild sedation. Expand
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