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Morgana and melusin: Two fairies chaperoning signal transduction
Morgana and melusin are described, two phylogenetically conserved chaperones that cooperate with Hsp90 and regulate signal transduction in important physiopathological processes.
Morgana acts as a proto‐oncogene through inhibition of a ROCK–PTEN pathway
It is demonstrated that high morgana expression in different breast cancer subtypes correlates with high tumour grade, mitosis number, and lymph node positivity and, from a mechanistic point of view, causes PTEN destabilization, by inhibiting ROCK activity, hence triggering the PI3K/AKT survival pathway.
Morgana acts as an oncosuppressor in chronic myeloid leukemia.
It is shown that morgana (+/-) mice spontaneously develop a lethal myeloproliferative disease resembling human atypical chronic myeloid leukemia (aCML), preceded by ROCK hyperactivation, centrosome amplification, and cytogenetic abnormalities in the bone marrow.
Characterization of human mitochondrial ferritin promoter: identification of transcription factors and evidences of epigenetic control
The expression of FTMT appears regulated by a complex mechanism involving epigenetic events and interplay between transcription factors and GATA2, FoxA1 and C/EBPβ as inhibitors of the transcriptional regulation.
Clinical significance of TFR2 and EPOR expression in bone marrow cells in myelodysplastic syndromes
Predicting, at diagnosis, those patients with risk of treatment failure is pivotal to personalize treatments in order to improve quality of life and prolong survival and whether the expression is associated with patients’ clinical outcomes.