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Innate and adaptive immunity in inflammatory bowel disease.
Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC). The exact cause of IBD remains unknown. Available evidence suggests that an abnormal immune responseExpand
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Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease
Background and aims: Epithelium derived interleukin (IL)-15 signalling via IL-15Rα is critical for the development, activation, and survival of intraepithelial lymphocytes (IEL). We aimed to betterExpand
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Differential regulation of interleukin 17 and interferon γ production in inflammatory bowel disease
Background and Aims: Interleukin 17 (IL17) is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel diseaseExpand
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Dendritic cells in intestinal homeostasis and disease.
DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or toleranceExpand
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A gut-vascular barrier controls the systemic dissemination of bacteria
A gut bacterial containment system Trillions of bacteria selectively inhabit our guts, but how do our bodies keep them contained? Spadoni et al. describe a “gut-vascular barrier” that preventsExpand
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Small Amounts of Gluten in Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial.
BACKGROUND & AIMS There is debate over the existence of nonceliac gluten sensitivity (NCGS) intestinal and extraintestinal symptoms in response to ingestion of gluten-containing foods by peopleExpand
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Anemia of chronic disease and defective erythropoietin production in patients with celiac disease
Anemia due to hematinic deficiencies is common in paients with untreated celiac disease. This study shows that, in addition to iron and vitamin deficiencies, anemia of chronic disease has aExpand
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Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin
Background Thymic stromal lymphopoietin (TSLP) is a cytokine with pleiotropic functions in the immune system. It has been associated with allergic reactions in the skin and lungs but also homeostaticExpand
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Transforming growth factor β signalling and matrix metalloproteinases in the mucosa overlying Crohn’s disease strictures
Background and Aims: In addition to its crucial role in dampening tissue-damaging immune responses in the gut, transforming growth factor β (TGFβ) is a potent profibrogenic agent inducing collagenExpand
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Serum bFGF and VEGF Correlate Respectively with Bowel Wall Thickness and Intramural Blood Flow in Crohn’s Disease
Serum levels of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF)—two factors known to promote tissue repair, fibroblast proliferation, and angiogenesis—wereExpand
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