A. Desmedt

Publications52
h-index23
Citations1,841
Highly Influential Citations106
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • A. Marighetto
  • 63 Publications • 2,483 Citations
  • Joseph E LeDoux
  • 572 Publications • 90,399 Citations
  • R. Jaffard
  • 182 Publications • 5,530 Citations
  • M. Fanselow
  • 360 Publications • 38,475 Citations
  • Publications
  • Influence
The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids
TLDR
In the hippocampus of the mutant mice after stress, as well as in the cell lines, activation of glucocorticoid receptors greatly increased the expression and enzymatic activity of proteins in the MAPK signaling pathway and led to an increase in the levels of both Egr-1 mRNA and protein.
View on Nature
Glucocorticoids Can Induce PTSD-Like Memory Impairments in Mice
TLDR
PTSD-like memory impairments in rodents are demonstrated and a potential pathophysiological mechanism of this condition is identified.
View on Publisher
Foreground contextual fear memory consolidation requires two independent phases of hippocampal ERK/CREB activation.
TLDR
It is revealed that the biphasic activation of ERK/CREB activity is independently regulated, yet both phases are critically required for the consolidation of long-term memories following unpaired fear conditioning.
View on PubMed
BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids
TLDR
The tPA-BDNF-TrkB signaling pathway is identified as the upstream molecular effectors of GR-mediated phosphorylation of Erk1/2MAPK responsible for the enhancement of contextual fear memory and is highlighted as one of the core effector of stress-related effects of GC.
View on Nature
A different recruitment of the lateral and basolateral amygdala promotes contextual or elemental conditioned association in Pavlovian fear conditioning.
TLDR
These findings refine the current model of the amygdala function in emotional learning by showing that the BLA and the LA not only differentially contribute to elemental and context-US association, but also promote, through their interaction, the most relevant of these two associations.
View on PubMed
Plasma transcortin influences endocrine and behavioral stress responses in mice.
TLDR
Findings uncover the critical role of plasma transcortin in providing an adequate endocrine and behavioral response to stress.
View on PubMed
The enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib
TLDR
The data provide a complete molecular pathway through which stress and glucocorticoids enhance the memory of stress-related events and highlight the function of synapsin-Ia/Ib as molecular effector of the behavioral effects of stress.
View on Nature
The amygdala and appraisal processes: stimulus and response complexity as an organizing factor
View on Elsevier
Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice
TLDR
This preclinical demonstration that S 24795 restored specific age-related memory deficits with as much efficacy as donepezil adds to recent literature in highlighting the potential interest of an α7 nAChR drug as a symptomatic AD therapeutic.
View on Springer
Dissociated roles for the lateral and medial septum in elemental and contextual fear conditioning.
TLDR
The present findings reveal a functional dissociation between the LS and the MS in Pavlovian fear conditioning depending on the predictive value of the discrete CS.
View on PubMed
...
...