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The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids
In the hippocampus of the mutant mice after stress, as well as in the cell lines, activation of glucocorticoid receptors greatly increased the expression and enzymatic activity of proteins in the MAPK signaling pathway and led to an increase in the levels of both Egr-1 mRNA and protein.
Glucocorticoids Can Induce PTSD-Like Memory Impairments in Mice
PTSD-like memory impairments in rodents are demonstrated and a potential pathophysiological mechanism of this condition is identified.
Foreground contextual fear memory consolidation requires two independent phases of hippocampal ERK/CREB activation.
It is revealed that the biphasic activation of ERK/CREB activity is independently regulated, yet both phases are critically required for the consolidation of long-term memories following unpaired fear conditioning.
BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids
The tPA-BDNF-TrkB signaling pathway is identified as the upstream molecular effectors of GR-mediated phosphorylation of Erk1/2MAPK responsible for the enhancement of contextual fear memory and is highlighted as one of the core effector of stress-related effects of GC.
A different recruitment of the lateral and basolateral amygdala promotes contextual or elemental conditioned association in Pavlovian fear conditioning.
These findings refine the current model of the amygdala function in emotional learning by showing that the BLA and the LA not only differentially contribute to elemental and context-US association, but also promote, through their interaction, the most relevant of these two associations.
Plasma transcortin influences endocrine and behavioral stress responses in mice.
Findings uncover the critical role of plasma transcortin in providing an adequate endocrine and behavioral response to stress.
The enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib
The data provide a complete molecular pathway through which stress and glucocorticoids enhance the memory of stress-related events and highlight the function of synapsin-Ia/Ib as molecular effector of the behavioral effects of stress.
The amygdala and appraisal processes: stimulus and response complexity as an organizing factor
Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice
- A. Marighetto, S. Valerio, A. Desmedt, J. Philippin, C. Trocmé-Thibierge, P. Morain
- Psychology, BiologyPsychopharmacology
- 12 February 2008
This preclinical demonstration that S 24795 restored specific age-related memory deficits with as much efficacy as donepezil adds to recent literature in highlighting the potential interest of an α7 nAChR drug as a symptomatic AD therapeutic.
Dissociated roles for the lateral and medial septum in elemental and contextual fear conditioning.
The present findings reveal a functional dissociation between the LS and the MS in Pavlovian fear conditioning depending on the predictive value of the discrete CS.